Abstract
Growth hormone (GH), as its name suggests, is obligatory for growth and development. It is, however, also required for sexual differentiation and pubertal maturation and participates in gonadal steroidogenesis and gametogenesis. These roles are likely to reflect the endocrine actions of pituitary GH, directly at gonadal sites and indirectly via hepatic insulin-like growth factor-1. However, because GH is also produced in gonadal tissues, it may act in paracrine or autocrine ways to regulate local processes that are strategically regulated by pituitary GH. The concept that GH is a major regulator of male reproduction is the focus of this review.
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Simpson, M. E., Marx, W., Becks, H., and Evans, H. M. (1944) Endocrinology 35, 309–316.
Ogilvy-Stuart, A. L. and Shalet, S. M. (1992). J. Endocrinol. 135, 405, 406.
Zachmann, M. (1992). Horm. Res. 38, 1–8.
Rivarola, M. A., Heinrich, J. J., Podesta, E. J., Chondjnik, M. F., and Bergada, C. (1972) Pediatr. Res. 6, 634–641.
Tanner, J. M. and Whitehouse, R. H. (1975). J. Clin. Endocrinol. Metab. 41, 788–790.
Laron, Z. (1984) Ergeb. Inn. Med. Kinderheilkd. 51, 117–150.
Arsenijevic, Y., Wehrenberg, W. B., Conz, A., Eskol, A., Sizonenko, P. C., and Aubert, M. L. (1989) Endocrinology 124, 3050–3059.
Hochereau-de Reviers, M. T., de Reviers, M. M., Monet-Kuntz, C., Perreau, L., Fontane, I., and Viguier-Martinez, M. C. (1997). Acta Endocrinol. 115, 399–405.
Van der Werff ten Bosch, J. J. and Bot, A. (1990). Clin. Endocrinol. 32, 707–717.
Stanhope, R., Albanese, A., Hindmarsh, P., and Brook, C. G. D. (1992). Horm. Res. 38 9–13.
Darendeliler, F., Hindmarsh, P. C., Preece, M. A., Cox, L., and Brook, C. G. D. (1990). Acta Endocrinol. 122, 414–416.
Balducci, R., Toscano, V., Mangiantini, A., Bianchi, P., Guglielmi, R., and Boscherini, B. (1993). Acta Endocrinol. 128, 19–23.
Zachmann, M. and Prader, A. (1970). J. Clin. Endocrinol. Metab. 30, 85–95.
Blok, G. J., de Boer, H., Gooren, L. J., and van der Veen, E. A. (1997). Clin. Endocrinol. 47, 29–36.
Nguyen, A. P., Chandorkar, A., and Gupta, C. (1996). Endocrinology 137, 3659–3666.
Matsushima, M., Kuroda, K., Shirai, M., Sugisaki, T., and Noguchi, T. (1986). Int. J. Androl. 9, 132–140.
Spiteri-Grech, J. and Nieschlag, E. (1992). Horm. Res. 38 (Suppl. 1), 22–27.
Bartlett, J. M., Charlton, H. M., Robinson, I. C., and Nieschlag, E. (1990). J. Endocrinol. 126, 193–201.
Laron, Z., and Klinger, B. (1998). Eur. J. Endocrinol. 138, 176–180.
Bartke, A., Chandrashekar, V., Turyn, D., et al. (1999). Proc. Soc. Exp. Biol. Med. 22, 113–123.
Bartke, A. (1965). Gen. Comp. Endocrinol. 5, 418–426.
Zipf, W. B., Payne, A. H., and Kelch, R. P. (1978). Endocrinology 103, 595–600.
Debeljuk, L., Steger, R. W., Wright, J. C., Mattison, J., and Bartke, A. (1999). Endocrine 11, 171–179.
Bartke, A., Naar, E. M., Johnson, L., et al. (1992), J. Repord. Fertil. 95, 109–118.
Singh, H., Griffith, R. W., Takahashi, A., Kawauchi, H., Thomas, P., and Stegeman, J. J. (1988). Gen. Comp. Endocrinol. 72, 144–153.
Bartke, A. (1999). Steroids 64, 598–604.
Boccabella, A. V. (1963). Endocrinology 72, 787–798.
Shoham, Z., Zalel, Y., and Jacobs, H. S. (1994). Clin. Endocrinol. 41, 1–5.
Gravance, C. G., Breier, B. H., Vickers, M. H., and Casey, P. J. (1997). Anim. Reprod. Sci. 49, 71–76.
Breier, B. H., Vickers, M. H., Gravance, C. G., and Casey, P. J. (1996). Endocrinology 137, 4061–4064.
Kuroda, K. (1989). Nippon. Hinyokika. Gakkai. Zasshi. 80, 3–10.
Huang, H. and Brown, D. D. (2000). Proc. Natl. Acad. Sci. USA, 97, 190–194.
Shimonovitz, S., Zacut, D., Benchetrit, A., and Ron, M. (1993). Hum. Reprod. 8, 919–921.
Lee, K. O., Ng, S. C., Lee, P. S., et al. (1995). Eur. J. Endocrinol. 132, 159–162.
Giagulli, V. A. (1999). Arch. Androl. 43, 47–53.
Ovesen, P., Jorgensen, J. O., Ingerslev, J., Ho, K. K., Orskov, H., and Christiansen, J. S. (1996). Fertil. Steril. 66, 292–298.
Shoham, Z., Conway, G. S., Ostergaard, H., Lahlou, N., Bouchard, P., and Jacobs, H. S. (1992). Fertil. Steril. 57, 1044–1051.
Radicioni, A., Paris, E., Dondero, F., Bonifacio, V., and Isidori, A. (1994). Acta Eur. Fertil 25, 311–317.
Zalel, Y., Draysen, E., Goldschmit, R., Zadik, Z., and Shoham, Z. (1996). Gynecol. Endocrinol. 10, 23–28.
Shoham, Z., Conway, G. S., Ostergaard, H., Lahlou, N., Bouchard, P., and Jacobs, H. S. (1992). Fertil. Steril. 57, 1044–1051.
Marchant, T. A., and Peter, R. E. (1986). J. Exp. Zool. 237, 231–239.
Sumpter, J. P., Lincoln, R. F., Bye, V. J., Carragher, J. F., and Le Bail, P. Y. (1991). Gen. Comp. Endocrinol. 83, 103–110.
Gomez, J. M., Loir, M., and Le Gac, F. (1998). Biol. Reprod. 58, 483–491.
Lechniak, D., Machnik, G., Szydlowski, M., and Switonski, M. (1999). Theriogenology 52, 1145–1152.
Ovesen, P., Jorgensen, J. O., Ingerslev, J., Orskov, H., and Christansen, J. S. (1998): Ugeskr. Laeger 160, 176–180.
Breier, B. H., Vickers, M. H., Gravance, C. G., and Casey, P. J. (1998), Endocrine J. 45 (Suppl.), S53-S60.
Glander, H. J., Kratzsch, J., Weisbrich, C., and Birkenmeier, G. (1996). Hum. Repord. 11, 2454–2460.
Miao, R., Lin, T. K., Bongso, T. A. Zhou, X., Cohen, P., and Lee, K. O. (1998). Clin. Endocrinol. 49, 235–239.
Pinkert, C. A., Kooyman, D. L., and Dyer, T. J. (1991). Biotechnology 16, 251–258.
Rexroad, C. E. (1991). In Transgenic animals. First, N. L. and Haseltine, F. P. (eds.), Butterworth-Heinemann: Boston.
Hammer, R. E., Brinster, R. L., Rosenfeld, M. G., Evans, R. M., and Mayo, K. E. (1985). Nature 315, 413–416.
Bartke, A., Steger, R. W., Hodges, S. L., et al. (1988). J. Exp. Zool. 248, 212–214.
Yun, J. S. and Wagner, T. E. (1987) Program of the 10th Korea Symposium on Science and Technology, Seoul, Korea 3, 279–282.
Bartke, A., Steger, R. W., Parkening, T. A., Collins, T., Yun, J. S., and Wagner, T. E. (1990) In Neuroendocrinology: new frontiers. Gupta, D., Wollman, H. A., and Ranke, M. B. (eds.), Brain Research Promotion: Tubingen, Germany.
Steger, R. W., Bartke, A., Parkening, T. A. et al. (1991). Neuroendocrinology 53, 365–372.
Bartke, A., Naar, E. M., Johnson, L., et al. (1992). J. Reprod. Fertil. 95, 109–118.
Frasier, S. D. (1999). J. Pediatr. 135, 278–279.
Sjogren, I., Jonsson, M., Madej, A., Johansson, H. E., and Ploen, L. (1998). Andrologia 30, 37–42.
Bertolloni, S., Baroncelli, G. I., Viacava, P., Massimetti, M., Simi, P., and Saggese, G. (1999). J. Pediatr. 135, 367–370.
Kanzaki, M., and Morris, P. L. (1999). Endocrinology 140, 1681–1686.
Chandrashekar, V., Bartke, A., Coschigamo, K., and Kopchick, J. (1999). Endocrinology 140, 1082–1088.
Kulin, H. E., Samdjlike, E., Santen, R., and Santer, S. (1981). Clin. Endocrinol. 45, 468–472.
Uy, J. S., Castro-Magana, M. and Angulo, M. A. (1991) J. Pediatr. Endocrinol. 4, 185–188.
Juul, A., Andersson, A., Pedersen, S. A., et al. (1998) Horm. Res. 49, 269–278.
Chatelain, P. G., Sanchez, P., and Saez, J. M. (1991). Endocrinology 128, 1857–1862.
Bex, F., Bartke, A., Goldman, B. D., and Dalterio, S. (1978). Endocrinology 103, 2069–2080.
Closset, J., Dombrowicz, D., and Vandenbroeck, M. (1991). Growth Regulat. 1, 29–37.
Le Gac, F., Ollitrault, M., Loir, M., and Le Bail, P. Y. (1992). Biol. Reprod. 46, 949–957.
Le Gac, F. and Loir, M. (1988). Reprod. Nutr. Dev. 28, 1031–1046.
Handelsman, D. J., Spaliviero, J. A., Scott, C. D., and Baxter, R. C. (1985), Acta Endocrinol. 109, 543–549.
Closset, J., Gothot, A., Sente, B., et al. (1989). Mol. Endocrinol. 3, 1125–1131.
Kanzaki, M. and Morris, P. L. (1988) Endocrinology 139, 1872–1882.
Untergasser, G., Hermann, M., Rumpold, H., and Berger, P. (1998). Eur. J. Endocrinol. 139, 424–427.
Untergasser, G., Kranewitter, W., Schwartzler, P., Madersbacher, S., Dirhnofer, S., and Berger, P. (1997). Mol. Cell Endocrinol. 130, 53–60.
Schwarzler, P., Untergasser, G., Hermann, M., et al. (1997). J. Clin. Endocrinol. Metab. 82, 3337–3341.
Untergasser, G., Kranewitter, W., Walser, F., Madersbacher, S., Dirhnofer, S., and Berger, P. (1996). Wiener Klin. Wochenschrift 108, 541–546.
Berger, P., Untergasser, G., Hermann, M., Hittmair, A., Madersbacher, S. and Dirhnofer, S. (1999) Hum. Pathol. 30, 1201–1206.
Harvey, S., Sharma, P., Johnson, C. D. M., Sanders, E. J., and Hull, K. L. (1998) Comp. Biochem. Physiol. C. 119, 305–315.
Pescovitz, O. H., Berry, S. A., Laudon, M. et al. (1990). Endocrinology 127, 2336–2342.
Berry, S. A., Srivastava, C. H., Rubin, L. R., Phipps, W. R., and Pescovitz, O. H. (1992). J. Clin. Endocrinol. Metab. 75, 281–284.
Moretti, C., Fabbri, A., and Gnessi, L. (1990). J. Endocrinol. Investi. 13, 301–305.
Monts, B. S., Breyer, P. R., Rothrock, J. K., and Pescovitz, O. (1996). Endocrine 4, 73–78.
Tsagarakis, S., Ge, F., Besser, G. M., and Grossman, A. (1991) Life Sci. 49, 1627–1634.
Pekary, A. E., Yameda, T., Sharp, B., Basin, S., Swerdloff, R. S., and Hershman, J. (1984). Life Sci. 34, 939–945.
Srivastava, C. H., Monts, B. S., Rothrock, J. K., Peredo, M. J., and Pescovitz, O. H. (1995). Endocrinology 136, 1502–1508.
Berry, S. A., Srivastava, C. H., Rubin, L. R., Phipps, W. R., and Pescovitz, O. H. (1992). Clin. Endocrinol. Metab. 75, 281–284.
Bagnato, A., Moretti, C., Frajese, G., and Catt, K. J. (1991). Endocrinology 128, 2889–2894.
Olchovsky, D., Bruno, J. F., and Berelowitz, M. (1996). J. Endocrinol. 148, 189–192.
Srivastava, C. H., Breyer, P. R., Rothrock, J. K., Peredo, M. J., and Pescovitz, O. H. (1993). Endocrinology 133, 1478–1481.
Matsubara, S., Sato, M., Mizobuchi, M., Niimi, M., and Takahara, J. (1995). Endocrinology 136, 4147–4150.
Srivastava, C. H., Kelley, M. R., Monts, B. S., Wilson, T. M., Breyer, P. R., and Pescovitz, O. H. (1994). Endocr. J. 2, 607–610.
Ciampani, T., Fabbri, A., Isidori, A., and Dufau, M. L. (1992). Endocrinology 131, 2785–2792.
Garcia-Aragon, J., Lobie, P. E., Muscat, G. E. O., Gobius, K., Norstedt, G., and Waters, M. J. (1992). Development 114, 869–876.
Lobie, P. E., Breipohl, W., Garcia-Aragon, J., and Waters, M. J. (1990). Endocrinology 126, 2214–2221.
Reiter, E., Bonnet, P., Sente, B., et al. (1992). Mol. Cell Endocrinol. 88, 77–87.
LeGac, F., Ollitrault, M., Loir, M., and Lebail, P. Y. (1992). Biol. Reprod. 46, 949–957.
D'Ercole, A. J., Stiles, A. D., and Underwood, L. E. (1984). Proc. Natl. Acad. Sci. USA 81, 935–939.
Lin, T., Wang, D., Calkins, H., Guo, H., Chi, R. and Housley, P. R. (1990). Mol. Endocrinol. 73, 147–152.
Lin, T., Haskell, J., Vinson, N., and Terracio, L. (1986). Endocrinology 119, 1641–1646.
Chatelain, P., Naville, D., and Saez, J. M. (1987). Biochem. Biophys. Res. Commun. 146, 1009–1017.
Ghosh, P. K. and Bartke, A. (1993). Transgenic. Res. 2, 79–83.
Ruan, W., Powell-Braxton, L., Kopchick, J., and Kleinberg, D. L. (1999). Endocrinology 140, 1984–1989.
Bondy, C. A., Zhou, J., Lupu, F., Bellve, A. R., and Efstradiatis, A. (1996). Mol. Endocrinol. 10, 903–318.
Reiter, E., Kecha, O., Hennuy, B., Lardinois, S., Klug, M., and Bruyninx, M. (1995) Endocrinology 136, 3338–3345.
Reiter, E., Hunnuy, B., Bryninx, M. et al. (1999). Prostate 38, 159–165.
Laron, Z. and Sarel, R. (1970). Acta Endocrinol. 63, 625.
Cacciari, E., Cicognani, A., Pirazzoli, P., et al. (1977). Helvetica Paediatr. Acta 31, 481–485.
Laron, Z., Mimouni, F., and Pertzelan, A. (1983). Isr. J. Med. Sci. 19, 338–344.
Ra, S., Aoki, H., Fujioka, T., Sato, F., Kubo, T., and Yasuda, N. (1996). J. Urol. 156, 522–525.
Jadresic, A., Banks, L. M., Child, D. F., et al. (1982). Quart. J. Med. 202, 189–189.
Fujita, K., Terada, H., and Ling, L. Z. (1997). Nippon Rinsho 55, 2908–2913.
Maneschi, F., White, M. C., Porta, M., and Kohner, E. M. (1981). Horm. Res. 14, 79–86.
Jellinck, P. H., Quail, J. A., and Crowley, C. A. (1985). Endocrinology 117, 2274–2278.
Singh, H. and Thomas, P. (1993). Gen. Comp. Endocrinol. 89, 341–353.
Apa, R., Caruso, A., Andreani, G., et al. (1996). Mol. Cell Endocrinol. 118, 95–101.
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Hull, K.L., Harvey, S. Growth hormone. Endocr 13, 243–250 (2000). https://doi.org/10.1385/ENDO:13:3:243
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DOI: https://doi.org/10.1385/ENDO:13:3:243