Abstract
Recent observations have shown that in lactating rats previously deprived of suckling, either suckling stimulus or ip injection of norepinephrine was capable of increasing mammary deiodinase type 1 (M-D1) mRNA content and enzyme activity. In the present work, we show that intact efferent sympathetic mammary innervation is required to restore both mammary D1 mRNA content and enzyme activity, whereas suckling-induced secretion of catecholamines from the adrenal glands does not seem to participate in M-D1 enzyme regulation. The data also indicate that the sympathetic reflex activation in response to suckling involves two complementary autonomic components: (1) activation, presumably through mammary segmental arrangement affecting neighboring mammary glands; and (2) an individual reflex regulatory mechanism capable of maintaining M-D1 activity within each mammary gland. In addition to these findings, we show that the suckling-induced sympathetic activation of M-D1 activity could be blocked by prior activation of ductal mechanoreceptors. This set of regulatory and counterregulatory mechanisms seems to ensure the optimal control of mammary energetic expenditure according to litter size.
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References
Larsen, P. R., Silva, J. E., Kaplan, M. M. (1981), Endocr. Rev. 2, 87–102.
Oppenheimer, J. H. and Samuels H. H. (eds.) (1983): Molecular Basis of Thyroid Hormone Action. Academic: New York.
Kohrle, J. (1994), Exp. Clin. Endocrinol. 102, 63–89.
Aceves, C., Navarro, L., Ramirez del Angel, A., Luna, M., and Valverde-R, C. (1994), Endocrine 2, 547–551.
Giralt M., Iglesias, R., Villarroya, F., and Mampel, T. (1987) Horm. Metab. Res. 19, 510–513.
Kahl, S., Capuco, A. V., and Bitman, J. (1987), Proc. Soc. Exp. Biol. Med. 184, 144–150.
Valverde-R, C. and Aceves, C. (1989), Endocrinology 124, 1340–1344.
Aceves, C., Morales, T., Pineda, O., Rodón-Fonte, C., Navarro, L., Valverde-R, C., and Mena, F. (1996). 5th International Symposium Hormonal Bioactive Substances in Milk. Slovak Republic.
Aceves, C., Pineda, O., Ramfrez, C. I., Navarro, L., and Valverde-R, C. (1999), Endocrinology 140, 2948–2953.
Mena, F., Clapp, C., Martínez-Escalera, G., Pacheco, P., Grosvenor, C. E. (1985). In: Oxytocin: Clinical and Laboratory Studies, Amico, J. A. and Robinson, A. G. (eds.), Elsevier: Amsterdam.
Grosvenor, C. E. and Mena, F. (1982). In: Neuroendocrine Perspectives, vol. 1, Muller, C.E.E. and McLeod, R. M. (eds.), Elsevier: Amsterdam.
Deis, R. P. (1968), J. Physiol. (Lond.) 197, 37–46.
Clapp, C., Martinez-Escalera, G., Morales, M. T., Shyr, S. W., Grosvenor, C. E., and Mena, F. (1985), Endocrinology 117, 2498–2504.
Mena, F., Aguayo, D., Pacheco, P., and Morales M. T. (1995). Neuroendocrinology 61, 722–730.
Memphan, T. B. (1987), Physiology of Lactation, Open University Press: Philadelphia.
Eriksson, M., Lindh, B., Uvnas-Morberg, K., and Hokfelt, T. (1996), Neuroscience 70, 227–245.
Marchetti, B., Fortier, M. A., Poyet, P., Follea, N., Pelletier, G., and Labrie, F. (1990), Endocrinology 126, 565–574.
Donoso, E. A., Sapag-Hagar, M., and Lara H. E. (1992), Mol. Cell. Neurosci. 8, 23–28.
Wakade, A. R. (1979), Nature 281, 374–376.
Aceves, C., Rodón, C., Ramfrez-C, I., Wilson, S., Pineda, O., López, L., Mancilla, R., and Valverde-R, C. (1995), Endocrine 3, 95–99.
Mena, F. and Grosvenor, C. E. (1968) Endocrinology 82, 623–626.
Leonard, J. L. and Rosenberg, I. N. (1980), Endocrinology 107, 1376–1383.
Chrigwin, J. M., Przybyla, A. E., McDonald, R. J., and Rutter, W. J. (1979), Biochemistry 18, 5294–5299.
Galton, V. A., Morganelli, C. M., Schneider, M. J., and Yee, K (1991), Endocrinology 129, 2298–2300.
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Aceves, C., Rojas-Huidobro, R., Marina, N. et al. Mammary gland sympathetic innervation is a major component in type 1 deiodinase regulation. Endocr 11, 115–121 (1999). https://doi.org/10.1385/ENDO:11:2:115
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DOI: https://doi.org/10.1385/ENDO:11:2:115