Advertisement

Clinical Reviews in Allergy & Immunology

, Volume 24, Issue 3, pp 221–228 | Cite as

Hypersensitivity reactions to non-beta-lactam antibiotics

  • Stephen A. Tilles
  • Christopher G. Slatore
Article

Abstract

As alternatives to beta lactam antibiotics continue to be developed, an increasing number of patients are experiencing hypersensitivity reactions to these agents. Unfortunately, unlike penicillin, there are no validated skin testing reagents to aid in confirming the presence of specific IgE antibodies to these drugs. This review summarizes what is known about hypersensitivity reactions to non-beta lactam antibiotics, and includes practical approaches to readministering these drugs in selected situations. Sulfonamides, vancomycin, macrolides, tetracyclines, fluoroquinolones, and anti-virals are included in the discussion.

Index Entries

Sulfonamides vancomycin macrolides tetracyclines fluoroquinolones anti-virals 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lazarou, J., Pomeranz, B. H., and Corey, P. N. (1998), JAMA 279, 1200–1205.PubMedCrossRefGoogle Scholar
  2. 2.
    deShazo, R. D. and Kemp, S. F. (1997), JAMA 278, 1895–1906.PubMedCrossRefGoogle Scholar
  3. 3.
    Gould, I. M. and Jappy, B. (2000) J. Antimicrob. Chemother. 45, 913–917.PubMedCrossRefGoogle Scholar
  4. 4.
    Rawlins, M. D. and Thompson, W. (1991), in Textbook of Adverse Drug Reactions, Daview, D. M., ed., Oxford University Press, New York, pp. 18–45.Google Scholar
  5. 5.
    Borish, L. and Tilles, S. A. (1998), in Immunology and Allergy Clinics of North America, vol. 18, Tilles, S. A., ed., W.B. Saunders Co. Philadelphia, pp. 717–730.Google Scholar
  6. 6.
    Kearns, G. L., Wheeler, J. G., Childress, S. H., et al. (1994), J. Pediatr. 125, 805–811.PubMedCrossRefGoogle Scholar
  7. 7.
    Sullivan, T. J. (1993), in Allergy: Principles and Practice. Middleton, E., et al., eds., Mosby, St. Louis, pp. 1726–1745.Google Scholar
  8. 8.
    Weiss, M. E. and Adkinson, N. F. (1998), in Imm. Allergy Clin. N. A., vol. 18, Tilles, S. A., ed., W.B. Saunders Co., Philadelphia, pp. 731–744.Google Scholar
  9. 9.
    Greenberger, P. A. (1998), in Imm. Allergy Clin. N.A., vol. 18, Tilles, S. A., ed., W.B. Saunders Co., Philadelphia, pp. 759–772.Google Scholar
  10. 10.
    Bernstein, I. L., Gruchalla, R. S., Lee, R. E., et al. (1999), Ann. Allergy Asthma Immunol. 83, 665–700.Google Scholar
  11. 11.
    Moreno, J., Poblete, R. B., Maggio, C., et al. (1995), Ann. Allergy Asthma Immunol. 74, 140–146.PubMedGoogle Scholar
  12. 12.
    Rich, J. D., Sullivan, T., and Greineder, D., et al. (1997), Ann. Allergy Asthma Immunol. 79, 409–414.PubMedGoogle Scholar
  13. 13.
    Anne, S., Middleton, E., and Reisman, R. E. (1994), Ann. Allergy 73, 402–404.PubMedGoogle Scholar
  14. 14.
    Wong, J. R., Ripple, R. E., MacLean, J. A., et al. (1994) J. Allergy Clin. Immunol. 94, 189–194.PubMedCrossRefGoogle Scholar
  15. 15.
    Jick, H. (1982), Rev. Inf. Dis. 4, 426–428.Google Scholar
  16. 16.
    Kucera, C. M. and Greenberger, P. A. (1996), Hosp. Med. 32, 11–24.Google Scholar
  17. 17.
    Montanaro, A. (1998), in Imm. Allergy Clin. N.A., vol. 18, Tilles, S. A., ed., W.B. Saunders Co., Philadelphia, pp. 843–850.Google Scholar
  18. 18.
    Bardicth-Crovo, P. and Chaisson, R. E. (1995), Emerg. Med. Clin. North Am. 13, 133–146.Google Scholar
  19. 19.
    Shear, N. H., Spielberg, S. P., Grant, D. M., et al. (1986), Ann. Intern. Med. 105, 179–184.PubMedGoogle Scholar
  20. 20.
    Harle, D. G., Baldo, B. A., and Wells, J. V. (1988), Mol. Immunol. 25, 1347–1354.PubMedCrossRefGoogle Scholar
  21. 21.
    Cribb, A. E., Lee, B. L., Trepanier, L. A., et al. (1996), Adverse Drug React. Toxicol. Rev. 15, 9–50.PubMedGoogle Scholar
  22. 22.
    Roujeau, J. C., Huynh, T. N., Bracq, C., et al. (1987), Arch. Dermatol. 123, 1171–1173.PubMedCrossRefGoogle Scholar
  23. 23.
    Vidal, C., Gonzalea Quintela, A., and Fuente, R. (1992), Ann. Allergy 68, 345–347.PubMedGoogle Scholar
  24. 24.
    Lerner, A. and Dwyer, J. M. (1984), Ann. Intern. Med. 100, 157.PubMedGoogle Scholar
  25. 25.
    Principi, N. and Esposito, S. (1999) Drug Saf. 20, 25–41.PubMedCrossRefGoogle Scholar
  26. 26.
    Gomez-Lechon, M. J., Carrasquer, J., Berenguer, J., and Castell, J. V. (1996), Clin. Exp. Allergy 26, 590–596.PubMedCrossRefGoogle Scholar
  27. 27.
    Jorro, G., Morales, C., Braso, J. V., and Pelaez, A. (1996), Ann. All, Asthma Immunol. 77, 456–458.CrossRefGoogle Scholar
  28. 28.
    Shapiro, L., Knowles, S., and Shear, N. (1997), Arch. Dermatol. 133, 1224–1230.PubMedCrossRefGoogle Scholar
  29. 29.
    Elkayam, O., Yaron, M., and Caspi, D. (1999), Semin. Arthritis Rheum. 28(6), 392–397.PubMedCrossRefGoogle Scholar
  30. 30.
    Owens, R. C. and Ambrose, P. G. (2000), Med. Clin. N.A. 84, 1447–1469.CrossRefGoogle Scholar
  31. 31.
    Davis, H., McGoodwin, E., and Greene Ree, T. (1989), Ann. Int. Med. 111, 1041–1043.PubMedGoogle Scholar
  32. 32.
    Matthews, M. R., Caruso, D. M., Phillips, B. J., and Csontos, L. G. (1999), Arch. Intern. Med. 159, 2225.PubMedCrossRefGoogle Scholar
  33. 33.
    Kawada, A., Hiruma, M., Noguchi, H., et al. (1996), Contact Dermatitis 34, 427–438.PubMedCrossRefGoogle Scholar
  34. 34.
    Erdem, G., Staat, M. A., Connelly, B. L., and Assa'ad, A. (1999), Pediatr. Infect. Dis. J. 18, 563–564.PubMedCrossRefGoogle Scholar
  35. 35.
    Whitley, R. J., Weiss, H., and Gnann, J. W., et al. (1996), Ann. Intern. Med. 125, 376–383.PubMedGoogle Scholar
  36. 36.
    Henry, R. E., Wegmann, J.A., Hartle, E. and Christopher, G.W. (1993). Ann. Allergy 70, 386–388.PubMedGoogle Scholar
  37. 37.
    Tancrede-Bohin, E., Grange, F., Bournerias, I., et al. (1996), Lancet 347, 971.PubMedCrossRefGoogle Scholar
  38. 38.
    Kawsar, M., Parkin, J. M., and Forster, G. (2001), Transm. Inf. 77, 204–205.CrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Stephen A. Tilles
    • 1
  • Christopher G. Slatore
    • 2
  1. 1.ASTHMA Inc.University of Washington School of MedicineSeattle
  2. 2.Department of MedicineUniversity of Washington School of MedicineSeattle

Personalised recommendations