Clinical Reviews in Allergy & Immunology

, Volume 24, Issue 3, pp 221–228 | Cite as

Hypersensitivity reactions to non-beta-lactam antibiotics

  • Stephen A. Tilles
  • Christopher G. Slatore


As alternatives to beta lactam antibiotics continue to be developed, an increasing number of patients are experiencing hypersensitivity reactions to these agents. Unfortunately, unlike penicillin, there are no validated skin testing reagents to aid in confirming the presence of specific IgE antibodies to these drugs. This review summarizes what is known about hypersensitivity reactions to non-beta lactam antibiotics, and includes practical approaches to readministering these drugs in selected situations. Sulfonamides, vancomycin, macrolides, tetracyclines, fluoroquinolones, and anti-virals are included in the discussion.

Index Entries

Sulfonamides vancomycin macrolides tetracyclines fluoroquinolones anti-virals 


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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Stephen A. Tilles
    • 1
  • Christopher G. Slatore
    • 2
  1. 1.ASTHMA Inc.University of Washington School of MedicineSeattle
  2. 2.Department of MedicineUniversity of Washington School of MedicineSeattle

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