Clinical Reviews in Allergy & Immunology

, Volume 18, Issue 2, pp 215–239 | Cite as

Xenobiotic-metabolizing enzymes as autoantigens in human autoimmune disorders

An update
  • Eric Boitier
  • Philippe Beaune


Several diseases are characterized by the presence of autoantibodies directed against either CYP or xenobiotic-metabolizing enzymes. They may be induced by toxic or idiopathic event. Very little is known about the mechanism of their triggering. When a toxic compound was identified, the metabolic part was quite well-characterized and variations of metabolism could be a risk factor in the development of the disease (e.g., dihydralazine-induced hepatitis). But in all the cases the abnormal immunological response is not understood, although it seems clear that the autoantibodies are not by themselves responsible for the disease.


Clinical Review Autoimmune Hepatitis Immunology Volume Reactive Metabolite Tienilic Acid 
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Copyright information

© Humana Press Inc. 2000

Authors and Affiliations

  1. 1.INSERM U 490, Toxicologie moléeculaireUniversité René DescartesParis Cedex 06France

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