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Hypersensitivity reactions to non-beta-lactam antibiotics

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Abstract

As alternatives to beta lactam antibiotics continue to be developed, an increasing number of patients are experiencing hypersensitivity reactions to these agents. Unfortunately, unlike penicillin, there are no validated skin testing reagents to aid in confirming the presence of specific IgE antibodies to these drugs. This review summarizes what is known about hypersensitivity reactions to non-beta lactam antibiotics, and includes practical approaches to readministering these drugs in selected situations. Sulfonamides, vancomycin, macrolides, tetracyclines, fluoroquinolones, and anti-virals are included in the discussion.

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References

  1. Lazarou, J., Pomeranz, B. H., and Corey, P. N. (1998), JAMA 279, 1200–1205.

    Article  PubMed  CAS  Google Scholar 

  2. deShazo, R. D. and Kemp, S. F. (1997), JAMA 278, 1895–1906.

    Article  PubMed  CAS  Google Scholar 

  3. Gould, I. M. and Jappy, B. (2000) J. Antimicrob. Chemother. 45, 913–917.

    Article  PubMed  CAS  Google Scholar 

  4. Rawlins, M. D. and Thompson, W. (1991), in Textbook of Adverse Drug Reactions, Daview, D. M., ed., Oxford University Press, New York, pp. 18–45.

    Google Scholar 

  5. Borish, L. and Tilles, S. A. (1998), in Immunology and Allergy Clinics of North America, vol. 18, Tilles, S. A., ed., W.B. Saunders Co. Philadelphia, pp. 717–730.

    Google Scholar 

  6. Kearns, G. L., Wheeler, J. G., Childress, S. H., et al. (1994), J. Pediatr. 125, 805–811.

    Article  PubMed  CAS  Google Scholar 

  7. Sullivan, T. J. (1993), in Allergy: Principles and Practice. Middleton, E., et al., eds., Mosby, St. Louis, pp. 1726–1745.

    Google Scholar 

  8. Weiss, M. E. and Adkinson, N. F. (1998), in Imm. Allergy Clin. N. A., vol. 18, Tilles, S. A., ed., W.B. Saunders Co., Philadelphia, pp. 731–744.

    Google Scholar 

  9. Greenberger, P. A. (1998), in Imm. Allergy Clin. N.A., vol. 18, Tilles, S. A., ed., W.B. Saunders Co., Philadelphia, pp. 759–772.

    Google Scholar 

  10. Bernstein, I. L., Gruchalla, R. S., Lee, R. E., et al. (1999), Ann. Allergy Asthma Immunol. 83, 665–700.

    Google Scholar 

  11. Moreno, J., Poblete, R. B., Maggio, C., et al. (1995), Ann. Allergy Asthma Immunol. 74, 140–146.

    PubMed  CAS  Google Scholar 

  12. Rich, J. D., Sullivan, T., and Greineder, D., et al. (1997), Ann. Allergy Asthma Immunol. 79, 409–414.

    PubMed  CAS  Google Scholar 

  13. Anne, S., Middleton, E., and Reisman, R. E. (1994), Ann. Allergy 73, 402–404.

    PubMed  CAS  Google Scholar 

  14. Wong, J. R., Ripple, R. E., MacLean, J. A., et al. (1994) J. Allergy Clin. Immunol. 94, 189–194.

    Article  PubMed  CAS  Google Scholar 

  15. Jick, H. (1982), Rev. Inf. Dis. 4, 426–428.

    CAS  Google Scholar 

  16. Kucera, C. M. and Greenberger, P. A. (1996), Hosp. Med. 32, 11–24.

    Google Scholar 

  17. Montanaro, A. (1998), in Imm. Allergy Clin. N.A., vol. 18, Tilles, S. A., ed., W.B. Saunders Co., Philadelphia, pp. 843–850.

    Google Scholar 

  18. Bardicth-Crovo, P. and Chaisson, R. E. (1995), Emerg. Med. Clin. North Am. 13, 133–146.

    Google Scholar 

  19. Shear, N. H., Spielberg, S. P., Grant, D. M., et al. (1986), Ann. Intern. Med. 105, 179–184.

    PubMed  CAS  Google Scholar 

  20. Harle, D. G., Baldo, B. A., and Wells, J. V. (1988), Mol. Immunol. 25, 1347–1354.

    Article  PubMed  CAS  Google Scholar 

  21. Cribb, A. E., Lee, B. L., Trepanier, L. A., et al. (1996), Adverse Drug React. Toxicol. Rev. 15, 9–50.

    PubMed  CAS  Google Scholar 

  22. Roujeau, J. C., Huynh, T. N., Bracq, C., et al. (1987), Arch. Dermatol. 123, 1171–1173.

    Article  PubMed  CAS  Google Scholar 

  23. Vidal, C., Gonzalea Quintela, A., and Fuente, R. (1992), Ann. Allergy 68, 345–347.

    PubMed  CAS  Google Scholar 

  24. Lerner, A. and Dwyer, J. M. (1984), Ann. Intern. Med. 100, 157.

    PubMed  CAS  Google Scholar 

  25. Principi, N. and Esposito, S. (1999) Drug Saf. 20, 25–41.

    Article  PubMed  CAS  Google Scholar 

  26. Gomez-Lechon, M. J., Carrasquer, J., Berenguer, J., and Castell, J. V. (1996), Clin. Exp. Allergy 26, 590–596.

    Article  PubMed  CAS  Google Scholar 

  27. Jorro, G., Morales, C., Braso, J. V., and Pelaez, A. (1996), Ann. All, Asthma Immunol. 77, 456–458.

    Article  CAS  Google Scholar 

  28. Shapiro, L., Knowles, S., and Shear, N. (1997), Arch. Dermatol. 133, 1224–1230.

    Article  PubMed  CAS  Google Scholar 

  29. Elkayam, O., Yaron, M., and Caspi, D. (1999), Semin. Arthritis Rheum. 28(6), 392–397.

    Article  PubMed  CAS  Google Scholar 

  30. Owens, R. C. and Ambrose, P. G. (2000), Med. Clin. N.A. 84, 1447–1469.

    Article  CAS  Google Scholar 

  31. Davis, H., McGoodwin, E., and Greene Ree, T. (1989), Ann. Int. Med. 111, 1041–1043.

    PubMed  CAS  Google Scholar 

  32. Matthews, M. R., Caruso, D. M., Phillips, B. J., and Csontos, L. G. (1999), Arch. Intern. Med. 159, 2225.

    Article  PubMed  CAS  Google Scholar 

  33. Kawada, A., Hiruma, M., Noguchi, H., et al. (1996), Contact Dermatitis 34, 427–438.

    Article  PubMed  CAS  Google Scholar 

  34. Erdem, G., Staat, M. A., Connelly, B. L., and Assa'ad, A. (1999), Pediatr. Infect. Dis. J. 18, 563–564.

    Article  PubMed  CAS  Google Scholar 

  35. Whitley, R. J., Weiss, H., and Gnann, J. W., et al. (1996), Ann. Intern. Med. 125, 376–383.

    PubMed  CAS  Google Scholar 

  36. Henry, R. E., Wegmann, J.A., Hartle, E. and Christopher, G.W. (1993). Ann. Allergy 70, 386–388.

    PubMed  CAS  Google Scholar 

  37. Tancrede-Bohin, E., Grange, F., Bournerias, I., et al. (1996), Lancet 347, 971.

    Article  PubMed  CAS  Google Scholar 

  38. Kawsar, M., Parkin, J. M., and Forster, G. (2001), Transm. Inf. 77, 204–205.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. ASTHMA Inc., University of Washington School of Medicine, Seattle, WA

    Stephen A. Tilles

  2. Department of Medicine, University of Washington School of Medicine, Seattle, WA

    Christopher G. Slatore

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  1. Stephen A. Tilles
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  2. Christopher G. Slatore
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Tilles, S.A., Slatore, C.G. Hypersensitivity reactions to non-beta-lactam antibiotics. Clinic Rev Allerg Immunol 24, 221–228 (2003). https://doi.org/10.1385/CRIAI:24:3:221

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  • DOI: https://doi.org/10.1385/CRIAI:24:3:221

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