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Xenobiotic-metabolizing enzymes as autoantigens in human autoimmune disorders

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Conclusion

Several diseases are characterized by the presence of autoantibodies directed against either CYP or xenobiotic-metabolizing enzymes. They may be induced by toxic or idiopathic event. Very little is known about the mechanism of their triggering. When a toxic compound was identified, the metabolic part was quite well-characterized and variations of metabolism could be a risk factor in the development of the disease (e.g., dihydralazine-induced hepatitis). But in all the cases the abnormal immunological response is not understood, although it seems clear that the autoantibodies are not by themselves responsible for the disease.

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  1. INSERM U 490, Toxicologie moléeculaire, Université René Descartes, 45, rue des Saints-Pères, Paris Cedex 06, France

    Eric Boitier & Philippe Beaune

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Boitier, E., Beaune, P. Xenobiotic-metabolizing enzymes as autoantigens in human autoimmune disorders. Clinic Rev Allerg Immunol 18, 215–239 (2000). https://doi.org/10.1385/CRIAI:18:2:215

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