Comprehensive Therapy

, Volume 32, Issue 2, pp 94–101 | Cite as

Pergolide-associated valvular heart disease

Original Articles


Pergolide is an ergot derivative dopamine agonist used in the treatment of Parkinson's disease and restless legs syndrome. Ergot derivatives are known to be associated with fibrotic conditions, including a carcinoid-like, fibrotic, valvular heart disease (VHD). Recently, pergolide was identified in association with the development of VHD. This article includes a summary of the literature published on pergolide-associated VHD, a description of the potential mechanisms of drug-induced VHD, and the clinical implications for the management of patients taking pergolide.


Bromocriptine Tricuspid Valve Cabergoline Pergolide Ergot Alkaloid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© ASCMS 2006

Authors and Affiliations

  1. 1.Department of Internal MedicineMayo ClinicJacksonville

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