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Cell Biochemistry and Biophysics

, Volume 46, Issue 3, pp 277–284 | Cite as

Flow-activated ion channels in vascular endothelium

  • Mamta Gautam
  • Andrea Gojova
  • Abdul I. Barakat
Review

Abstract

The ability of vascular endothelial, cells (ECs) to respond to fluid mechanical forces associated with blood flow is essential for flow-mediated vasoregulation and arterial wall remodeling. Abnormalities in endothelial responses to flow also play a role in the development of atherosclerosis. Although our understanding of the endothelial signaling pathways stimulated by flow has greatly increased over the past two decades, the mechanisms by which ECs sense flow remain largely unknown. Activation of flow-sensitive ion channels is among the fastest known endothelial responses to flow; therefore, these ion channels have been proposed as candidate flow sensors. This review focuses on: 1) describing the various types of flow-sensitive ion channels that have been reported in ECs, 2) discussing the implications of activation of these ion channels for endothelial function, and 3) proposing candidate mechanisms for activation of flow-sensitive ion channels.

Index Entries

Ion channels Endothelial cells Shear stress Atherosclerosis Flow Mechanotransduction 

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Copyright information

© Humana Press Inc 2006

Authors and Affiliations

  • Mamta Gautam
    • 1
  • Andrea Gojova
    • 1
  • Abdul I. Barakat
    • 1
  1. 1.Department of Mechanical and Aeronautical EngineeringUniversity of CaliforniaDavis

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