Cell Biochemistry and Biophysics

, Volume 41, Issue 2, pp 193–205 | Cite as

Sharpening the scissors

Mitochondrial fission with aid
  • Yisang Yoon
Review Article


Over the past 5 yr. research in mitochondrial morphology has advanced rapidly, mainly as a result of the identification of protein factors involved in mitochondrial fission and fusion. The pathological relevance of these processes becomes clear as apoptotic cell death evidently involves mitochondrial fission and fusion machinery. Although the mechanisms by which cells maintain mitochondrial morphology are now beginning to be understood, interrelation between mitochondrial function and morphology is still not clear. This review describes the recent progress made in mitochondrial fission studies and ventures to seek an intricate link between morphology and function of mitochondria.

Index Entries

Mitochondria dynamics fission fusion DLP1 dynamin hFisl GTPase 


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© Humana Press Inc 2004

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of Rochester School of Medicine and DentistryRochester
  2. 2.Department of Pharmacology and PhysiologyUniversity of Rochester School of Medicine and DentistryRochester

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