Biological Trace Element Research

, Volume 95, Issue 2, pp 107–112 | Cite as

Levels of zinc and magnesium in senile and diabetic senile cataractous lenses

  • Güray Gündüz
  • Filiz Gündüz
  • ıclal Yücel
  • Ümit Kemal Şentürk


Zinc and magnesium in serum, hair, and lens were determined in diabetic and nondiabetic patients who have been operated because of senile cataract. Both trace elements were measured by atomic absorption spectrometry, after acidic digestion of the lens and hair samples. Although there was no difference in serum, lens, and hair levels of magnesium between the two groups, the lens levels of zinc in diabetic patients (0.56±0.05 µmol/g dry weight) were significantly higher as compared with nondiabetic group (0.42±0.03 µmol/g dry weight). There was no statistically significant difference in serum and hair levels of zinc between the groups. The increased concentration of zinc in the lens of diabetic patients suggests that zinc might play a role in developmental mechanism of the diabetic senile cataract.

Index Entries

Diabetes lens cataract zinc magnesium 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D. Garland, Role of site specific, metal-catalyzed oxidation in lens aging and cataract: a hypothesis, Exp. Eye Res. 50, 677–682 (1990).PubMedCrossRefGoogle Scholar
  2. 2.
    M. A. Kass, F. G. Berson, L. A. Gans, D. J. Schanzlin, and B. J. Shingleton, The lens, K. A. Hecht, B. Nichols, and J. V. Bueren eds., American Academy of Ophthalmology, San Francisco, CA, Sect. pp. 102–150 (1990–1991).Google Scholar
  3. 3.
    V. Rasi, S. Constantini, and A. Moramarco, Inorganic element concentrations in cataractous human lenses, Ann. Ophthalmol. 24, 459–464 (1992).PubMedGoogle Scholar
  4. 4.
    J. D. Wilmor and D. F. Foster, Diabetes mellitus, in Williams’ Textbook of Endocrinology, R. H. Unger and D. W. Foster eds., W. B. Saunders, Philadelphia, pp. 505–1994 (1992).Google Scholar
  5. 5.
    A. Stanojevic, V. Hristil, and M. Cuperlovic, Macro and microelements in the cataractous eye lens, Ophthal. Res. 19, 230–234 (1987).CrossRefGoogle Scholar
  6. 6.
    X. Hou and Y. Hou, Determination of 19 elements in human eye lenses, Biol. Trace Element Res. 55, 89–98 (1996).CrossRefGoogle Scholar
  7. 7.
    A. Sethi, K. Nath, N. Ahmad, K. P. Gupta, and O. Chandra, A study of trace elements in human cataractous lenses and sera, Indian J. Ophthalmol. 35, 201–203 (1987).PubMedGoogle Scholar
  8. 8.
    V. K. Srivastava, N. Varshney, and D. C. Pandey, Role of trace elements in senile cataract, Acta Ophthalmol. 70, 839–841 (1992).CrossRefGoogle Scholar
  9. 9.
    J. Brando-Neto, C. A. Silva, N. B. Figueiredo, T. Shuhama, M. B. Hollanda, and J. M. Diniz, Zinc kinetics in insulin-dependent diabetes mellitus patients, BioMetals 13, 141–143 (2000).CrossRefGoogle Scholar
  10. 10.
    H. W. Valk, Magnesium in diabetes mellitus, Neth. J. Med. 54, 139–146 (1999).PubMedCrossRefGoogle Scholar
  11. 11.
    M. W. Aguilar, J. M. Laborda, M. C. Martinez-Para, et al., Effect of diabetes on the tissular Zn/Cu ratio, J. Trace Elements Med. Biol. 12, 155–158 (1998).Google Scholar
  12. 12.
    R. Gupta, V. K. Garg, D. K. Mathur, and R. K. Goyal, Oral zinc therapy in diabetic neuropathy, J Assoc Physicians India 46, 939–942 (1998).PubMedGoogle Scholar
  13. 13.
    X. Liu and Y. Zhang, Study on change in zinc concentration for diabetic cataractous lenses in rats by means of XIXA, Hsueh. Pao. 21, 134–136 (1990).Google Scholar
  14. 14.
    B. L. Vallee and K. H. Falchuk, The biochemical basis of zinc physiology, Physiol. Rev. 73, 79–118 (1993).PubMedGoogle Scholar
  15. 15.
    G. Chittleborough, A chemist’s view of the analysis of human hair for trace elements, Sci. Total Environ. 14, 53–75 (1980).PubMedCrossRefGoogle Scholar
  16. 16.
    M. D. Chen, P. Y. Lin, and C. T. Tsau, Selected metals status in patients with noninsulin-dependent diabetes mellitus, Biol. Trace Element Res. 50, 119–124 (1995).Google Scholar
  17. 17.
    C. Ruiz, A. Alegria, and R. Barbera, Selenium, zinc and copper in plasma of patients with diabetes mellitus different metabolic control states, J. Trace Elements Med. Biol. 12, 91–95 (1998).Google Scholar
  18. 18.
    C. Terres-Martos, A. M. Navarro, and L. F. Martin, Serum zinc and copper concentrations and Cu-Zn ratios in patients with hepatopathies or diabetes, J. Trace Elements Med. Biol. 12, 44–49 (1998).Google Scholar
  19. 19.
    N. R. Williams, W. J. Rajput, and J. A. West, Plasma, granulocyte and mononuclear cell copper and zinc in patients with diabetes mellitus, Analyst 120, 887–890 (1995).PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc 2003

Authors and Affiliations

  • Güray Gündüz
    • 1
  • Filiz Gündüz
    • 2
  • ıclal Yücel
    • 1
  • Ümit Kemal Şentürk
    • 2
  1. 1.Department of OphthalmologyAkdeniz UniversityAntalyaTurkey
  2. 2.Department of Physiology, School of MedicineAkdeniz UniversityAntalyaTurkey

Personalised recommendations