Biological Trace Element Research

, Volume 92, Issue 2, pp 115–121 | Cite as

Effects of chronic fluorosis on electrocardiogram in sheep

  • Nurcan Dönmez
  • Ali Çinar


This study was carried out to evaluate the effects of chronic fluorosis by means of the electrocardiograms in sheep. Ten sheep with fluorosis living around a volcanic mountain (Tendürek Mount) in East Anatolia in Turkey and 10 healthy sheep were used. Leads I, II, III, aVR, aVL, aVF, V2, V4, and V10 were recorded in the electrocardiographs of the sheep. All waves were seen in all derivations. The P-Q interval was significantly (p<0.05) prolonged and sinus bradycardia was observed in the sheep with fluorosis. As a result of this, the number of heart beats was decreased significantly (p<0.05); that is, the number of heart beats was 110±15 in the control group and 75±10 in sheep with fluorosis.

Index Entries

Fluorosis fluoride ECG sheep bradycardia 


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  1. 1.
    H. Rubin Carol and K. Noji Eric, Evaluating a fluorosis hazard after a volcanic eruption, Arch. Environ. Health 49(5), 395–403 (1994).CrossRefGoogle Scholar
  2. 2.
    I. E. Coop, Sheep and Goat Production. World Animal Science, Cl., New York (1982).Google Scholar
  3. 3.
    WHO, Fluorides and Oral Health. Report of WHO Expert Committee on Oral Health Status and Fluoride Use, WHO, Geneva (1994).Google Scholar
  4. 4.
    H. S. Ergün, H. A. Rüssel-Sinn, N. Bayşu, et al., Studies on the fluoride contents in water and soil. Urine, bone and teeth of sheep and urine of human from eastern and western parts of Turkey, DTW 94, 416–420 (1987).Google Scholar
  5. 5.
    K. N. Burns and R. Allcroft, Fluorosis, Vet. Rec. 76(18), 507–509 (1964).Google Scholar
  6. 6.
    I. D. Brouwer, O. Bockerdirks, A. Debruin, et al., Unsuitability of world health organization guidelines for fluoride concentrations in drinking water in Senegal, Lancet 30, 223–225 (1988).CrossRefGoogle Scholar
  7. 7.
    S. L. Choubisa, Some observations on endemic fluorosis in domestic animals in Southern Rajasthan (India), Vet. Res. Commun. 23, 457–465 (1999).PubMedCrossRefGoogle Scholar
  8. 8.
    A. Bildik, Florozisli koyunlarda kan serumundaki iyot değerleri ile bazı spesifik karaciğer enzim aktivitelerinin araştırılması, PhD thesis, Yüzüncü Yil University, Van, Turkey (1992).Google Scholar
  9. 9.
    N. Maraşlı, Research on the levels triiodothyronine (T3) and thyroxine (T4) in normal sheep and sheep with fluorosis, PhD thesis. Ankara University, Ankara (1991).Google Scholar
  10. 10.
    T. Sel, Serum levels of specific liver enzymes (glutamate oxalacetate transaminase, glutamate pyruvate transaminase, lactate dehydrogenase) and alkaline phosphatase in normal sheep and sheep showing sings of fluorosis in Eastern Anatolia, PhD thesis, Ankara University, Ankara (1991).Google Scholar
  11. 11.
    B. Yılmaz, Physiology, Feryal Matbaacılık. Ankara (2000).Google Scholar
  12. 12.
    T. Konuk, Practise Physiology, A. Ü. Vet. Fak. Yayınları. Ankara (1981).Google Scholar
  13. 13.
    G. Zhi-zhong, J. Zong, Y. Pei Shei, et al., Synergistic action of iodine. Deficiency and fluorine-intoxication on rat thyroid, Chin. Med. J. 101(9), 679–684 (1988).Google Scholar

Copyright information

© Humana Press Inc 2003

Authors and Affiliations

  • Nurcan Dönmez
    • 1
  • Ali Çinar
    • 1
  1. 1.Department of Physiology, Veterinary FacultyYüzüncü Yıl UniversityVanTurkey

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