Biological Trace Element Research

, Volume 92, Issue 1, pp 11–15 | Cite as

Changes of total content of magnesium and zinc status in patients with chronic toxoplasmosis

  • Süleyman Yazar
  • Eser Kilic
  • Recep Saraymen


The aim of this study was to investigate the effects of the Toxoplasma gondii infection on the total content of the essential elements Zn and Mg levels. Plasma zinc and magnesium concentrations were measured in 158 patients whose anti-T gondii IgG antibodies were positive. Scores were obtained for the patients and their age- and sex-matched 82 sero-negative healthy controls. The mean concentration of Mg in blood was significantly lower in sero-positive patients than in their controls both in females (p<0.01) and males (p<0.01). The average Zn concentration in seropositive female patients was 0.72±0.2 mg/L and 0.65±0.1 mg/L in controls (p>0.05). The mean values of the Zn in blood were 1.00±0.3 mg/L in seropositive male patients and 0.84±0.2 in controls (p>0.05). No correlation could be demonstrated between age and mean values of Zn and Mg in both sero-positive females/males and controls (p>0.05). No significant correlation could be found between blood Zn and Mg levels in seropositive female/male patients and controls (p>0.05). Mg levels were found to be clearly decreased in the patients with chronic toxoplasmosis, whereas no change was observed in Zn levels.

Index Entries

Toxoplasma gondii zinc magnesium 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J. G. Montaya, Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis, J. Infect. Dis. 15(185), 73–82 (2002).CrossRefGoogle Scholar
  2. 2.
    Y. Suzuki, Host resistance in the brain against Toxoplasma gondii, J. Infect. Dis. 15(185), 58–65 (2002).CrossRefGoogle Scholar
  3. 3.
    A. M. Tenter, A. R. Heckeroth, and L. M. Weiss, Toxoplasma gondii: from animals to humans, Int. J. Parasitol. 30(12–13), 1217–1258 (2000).PubMedCrossRefGoogle Scholar
  4. 4.
    A. K. Deorari, S. Broor, R. S. Maitreyi, et al., Incidence, clinical spectrum, and outcome of intrauterine infections in neonates, J. Trop. Pediatr. 46(3), 155–159 (2000).PubMedCrossRefGoogle Scholar
  5. 5.
    J. L. Smith, Foodborne infections during pregnancy, J. Food Protect. 62(7), 818–829 (1999).Google Scholar
  6. 6.
    E. J. Jareno, F. Bosch-Morell, R. Fernandez-Delgado, et al., Plasma malondialdehyde in HIV-seropositive children negatively correlates with CD4+ lymphocytes count, Biofactors 8(1–2), 129–132 (1998).PubMedGoogle Scholar
  7. 7.
    A. Sonnerborg, G. Carlin, B. Akerlund, et al., Increased production of malondialdehyde in patients with HIV infection, Scand. J. Infect. Dis. 20(3), 287–290 (1988).PubMedGoogle Scholar
  8. 8.
    A. Leonard, G. B. Gerber, and F. Leonard, Mutagenicity, carcinogenicity and teratogenicity of zinc, Mutat. Res. 168, 343–353 (1986).PubMedGoogle Scholar
  9. 9.
    N. Wellinghausen, W. Jochle, S. Reuter, et al., Zinc status in patients with alveolar echinococcosis is related to disease progression, Parasite Immunol. 21(5), 237–241 (1999).PubMedCrossRefGoogle Scholar
  10. 10.
    G.B. Vega Robledo, J.C. Carrero, and L. Ortiz-Ortiz, Effect of zinc on Entamoeba histolytica pathogenicity, Parasitol. Res. 85(6), 487–492 (1999).PubMedCrossRefGoogle Scholar
  11. 11.
    R. Kupka and W. Fawzi, Zinc nutrition and HIV infection, Nutr. Rev. 60(3), 69–79 (2002).PubMedCrossRefGoogle Scholar
  12. 12.
    S. Michelle, P. Alain, and B. Françoise, Minerals, trace elements and related biological variables in athletes and during physical actvity, Clin. Chim. Acta 321, 1–11 (2001).Google Scholar
  13. 13.
    T.C. Jones, R.D. Hunt, and N.W. King, Veterinary Pathology, 6th ed., Williams & Wilkins, A Waverly Company, Baltimore, MD USA (1996).Google Scholar

Copyright information

© Humana Press Inc 2003

Authors and Affiliations

  • Süleyman Yazar
    • 1
  • Eser Kilic
    • 2
  • Recep Saraymen
    • 2
  1. 1.Department of ParasitologyErciyes University, Medical FacultyKauseriTurkey
  2. 2.Department of Biochemistry and Clinical BiochemistryErciyes University, Medical FacultyKayseriTurkey

Personalised recommendations