Biological Trace Element Research

, Volume 88, Issue 3, pp 255–269 | Cite as

Excessive hepatic copper accumulation in jaundiced rats fed a high-copper diet

  • S. Yu
  • R. van der Meer
  • A. C. Beynen


The response of copper metabolism to dietary copper challenge was investigated in jaundiced rats with elevated plasma concentrations of conjugated bilirubin as a result of impaired canicular transport of bilirubin glucuronides. Control and jaundiced rats were fed purified diets with either normal (64 µmol Cu/kg) or high (640 µmol Cu/kg) concentration of added copper. Copper loading produced a greater increase in hepatic copper concentrations in the jaundiced than in control rats. The greater dietary-copper-induced increase in hepatic copper in the jaundiced rats can be explained by the observed smaller rise in biliary copper excretion and a greater efficiency of dietary copper absorption. In individual rats, there was a positive relationship between hepatic copper concentrations and biliary copper concentrations. It is suggested that not the transport of copper from liver cells to bile but that from plasma to bile is diminished in the jaundiced rats. The elevated plasma copper concentrations in the jaundiced rats may support this suggestion.

Index Entries

Jaundice rats copper bile 


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Copyright information

© Humana Press Inc 2002

Authors and Affiliations

  • S. Yu
    • 1
  • R. van der Meer
    • 2
  • A. C. Beynen
    • 1
  1. 1.Department of Nutrition, Faculty of Veterinary MedicineUtrecht UniversityUtrechtThe Netherlands
  2. 2.Department of NutritionNetherlands Institute for Dairy ResearchEdeThe Netherlands

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