Zinc and copper in Indian patients of tuberculosis
- 114 Downloads
The effectiveness and success of antitubercular therapy is mainly measured by identifying the organism in sputum. In certain patients, especially in geriatric patients, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness of antitubercular therapy, as the symptoms might be confused with the existing symptoms of ongoing diseases. Therefore, 60 diagnosed and randomly selected patients with tuberculosis were included into this study. The patients with other associated diseases likely to influence serum copper and zinc were not included in the study. The estimations of serum copper and zinc were done in healthy volunteers and in tubercular patients before the start of treatment and after 4 wk of antitubercular treatment. The average plasma concentration of serum copper and zinc in healthy volunteers were 102±20 μg/dL and 96±18 μg/dL respectively. In tuberculosis patients, serum copper and zinc levels were 123.65±9.98 μg/dL and 64.14±3.97 μg/dL, respectively, before the start of treatment, which came down to 116.23±4.27 μg/dL and 74.31±3.60 μg/dL, respectively, after 4 wk of antitubercular treatment.
Index EntriesSerum zinc serum copper tuberculosis antitubercular drugs trace elements
Unable to display preview. Download preview PDF.
- 1.J. N. Bodgen, D. I. Lintz, M. M. Joselow, et al., Effect of pulmonary tuberculosis on blood concentration of copper and zinc, Am. J. Clin. Pathol., 67, 251–256 (1977).Google Scholar
- 2.R. K. Chandra, Trace elements and immune responses, in Trace Elements in the Nutrition of Children, R. K. Chandra, ed., Raven, New York (1989).Google Scholar
- 3.B. Cabrer, D. Bonfill, A. Grau, et al., Tuberculosis, pleural effusion and pleural effusion secondary to non specific bacterial infection: biochemical differential diagnosis, Med. Clin. 74, 89–92 (1980).Google Scholar
- 5.F. J. Underwood, Trace Elements in Human and Animal Nutrition, Academic, New York, pp. 68–73, 214–216 (1971).Google Scholar
- 6.W. R. Biesel, R. S. Pekarek, and R. W. Wannemacker, The impact of infectious disease on trace element metabolism of the host, in Trace Element Metabolism in Animals, W. G. Hoekstra, J. W. Suttie, and H. F. Ganther, eds., University Park Press, Baltimore, MD, pp. 217–240 (1974).Google Scholar
- 7.D. Morse, D. R. Brothwell, and P. Ucko, Tuberculosis in ancient Egypt, Lancet 3, 524–541 (1964).Google Scholar
- 8.B. Sharda and B. Bhandari, Serum zinc in childhood pulmonary tuberculosis, Indian Paediatr. 14, 195–196 (1997).Google Scholar
- 9.P. C. Khatri, B. D. Gupta, M. Miglani, and A. Jain, Serum zinc in pulmonary infection, Indian Paediatr. 18, 120–124 (1981)Google Scholar
- 10.B. K. Khanna, R. L. Kumar, P. K. Mukherjee, A. R. Chaudhary, and V. P. Kamboj, Plasma copper and zinc levels in pulmonary tuberculosis, Indian J. Tuberculosis 29, 179–181 (1982).Google Scholar
- 11.E. Karyadi, C. E. West, W. Schultink, et al., A double blind placebo-controlled study of vit A & zinc supplimentation in persons with tuberculosis in Indonesia. Effects on clinical response and nutritional status, Am. J. Clin. Nutri. 75, 720–27 (2002).Google Scholar