Biological Trace Element Research

, Volume 109, Issue 2, pp 115–121 | Cite as

Long-term changes in trace elements in patients undergoing chronic hemodialysis

  • Yi-Yueh Hsieh
  • Wu-Shiun Shen
  • Li-Yu Lee
  • Tsu-Lan Wu
  • Hsiao-Chen Ning
  • Chien-Feng Sun


Although the connection between aluminum intoxication and dialysis dementia was identified in the 1980s, understanding of trace element imbalances in hemodialysis patients is as yet incomplete. Recent application of newer inductively coupled plasma-mass spectrometry (ICP/MS) techniques has resulted in renewed study of this population. We used ICP/MS to evaluate serum concentrations of Cu, Se, Zn, Mn, and Ni in a relatively large population of hemodialysis patients compared with healthy age-matched controls. Comparison were also done by duration of hemodialysis treatment to see whether length of treatment correlates with severity of imbalance. Patients had significantly lower concentrations of the three elements Se, Zn, and Mn. Patients had significantly higher concentrations of Ni, and there was a positive correlation between duration and severity of imbalance for this one element. There was no difference in Cu concentrations between patients and controls. Our findings confirm relative Ni excess and deficiencies of Se, Zn, and Mn in hemodialysis patients, documenting the value of ICP/MS in research work on trace element imbalances as well as clinical monitoring of individual patients.

Index Entries

Hemodialysis selenium zinc manganese nickel copper inductively coupled plasma-mass spectrometry (ICP/MS) 


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Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Yi-Yueh Hsieh
    • 1
  • Wu-Shiun Shen
    • 2
  • Li-Yu Lee
    • 1
  • Tsu-Lan Wu
    • 2
  • Hsiao-Chen Ning
    • 2
  • Chien-Feng Sun
    • 2
  1. 1.Department of PathologyChang Gung Memorial Hospital, Lin-Kuo Medical CenterTao-YuanTaiwan
  2. 2.Department of Clinical PathologyChang Gung Memorial Hospital, Lin-Kuo Medical CenterTao-YuanTaiwan

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