Abstract
Seven zinc salts—acetate, chloride, lactate, sulfate, citrate, gluconate, and oxide—were added to milk—and soy-based infant formulas to estimate possible differences in zinc availability depending on the type of salt used. For this purpose, an in vitro method that estimates the dialyzability of the element (i.e., the fraction available for absorption) was applied. Zinc dialyzability is always higher in milk-based products than in soy products, even when the total zinc contents are higher in the latter.
The salts can be classified according to the zinc dialyzability in the two types of formulas as follows: oxide>gluconate=chloride=lactate>citrate=acetate>sulfate. Therefore, according to the dialysis percentage, oxide and gluconate are the compounds of choice for zinc supplementation of infant formulas.
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References
J. A. Milner, Trace minerals in the nutrition of children, J. Pediatr. 117, S147-S155 (1990).
B. Sandström, Bioavailability of zinc, Eur. J. Clin. Nutr. 51(Suppl. 1), S17-S19 (1997).
A. H. Shankar and A. S. Prassad, Zinc and inmune function:the biological basis of altered resistance to infection, Am. J. Clin. Nutr. 68(Suppl. 2), 447S-463S (1998).
I. Lombeck and A. Fuchs, Zinc and copper in infants fed breast-milk or different formula, Eur. J. Pediatr. 153, 770–776 (1994).
National Research Council (NRC), Recommended Dietary Allowances, 10th ed., National Academy of Sciences, Washington, DC (1989).
B. Lönnerdal, M. Yuen, and M. S. Huang, Calcium, iron, zinc, copper and manganese bioavailability from infant formulas and weaning diets assessed in rat pups, Nutr. Res. 14, 1535–1548 (1994).
P. A. Walravens and K. M. Hambidge, Growth of infants fed a zinc supplemented formula, Am. J. Clin. Nutr. 29, 1114–1121 (1976).
A. Higashi, T. Ikeda, Y. Uehara, and Y. Matsuda, Effect of low content zinc and copper formula on infant nutrition, Eur. J. Pediatr. 138, 237–240 (1982).
F. Jochum, A. Fuchs, A. Cser, H. Menzel, and I. Lombeck, Trace mineral status of full-term infants fed human milk, milk-based formula or partially hydrolysed whey, Analyst 120, 905–909 (1995).
L. Salmenperä, J. Perheentupa, V. Nantö, and M. A. Siimes, Exclusively breast-fed healthy infants grow slower than reference infants, Pediatr. Res. 19, 307–312 (1985).
L. Salmenperä, J. Perheentupa, P. Pakarinen, and M. A. Siimes, Zinc supplementaton of infant formula, Am. J. Clin. Nutr. 59, 985–989 (1994).
L. Schlesinger, M. Arevalo, S. Arredondo, M. Diaz, B. Lönnerdal, and A. Stekel, Effect of a zinc-fortified formula on immunocompetence and growth of malnourished infants, Am. J. Clin. Nutr. 56, 491–498 (1992).
J. K. Friel, W. L. Andrews, J. D. Matthew, R. D. Long, A. M. Corned, M. Cox, et al., Zinc supplementation in very low birth weight infant, J. Pediatr. Gastroenterol. Nutr. 17, 97–104 (1993).
EEC: Commission Directive 91/321/EEC of 14 May 1991 on infant formulae and follow-on formulae. No. L175, 4/7/1991, pp. 35–49.
D. D. Miller, B. R. Schricker, R. R. Rasmussen, and D. Van Campen, An in vitro method for estimation of iron availability from meals, Am. J. Clin. Nutr. 34, 2248–2256 (1981).
J. Luten, H. Crews, A. Flynn, P. Van Dael, P. Kastenmayer, R. Hurrell, et al., Interlaboratory trial on the determination of the in vitro iron dialysability from food, J. Sci. Food Agric. 72, 415–424 (1996).
B. Lönnerdal, Nutritional aspects of soy formula, Acta Paediatr. 83(Suppl. 402), 105–108 (1994).
B. Lönnerdal, A. Cederblad, A. Davidsson, and B. Sandström, The effect of individual components of soy formula and cow’s milk formula on zinc bioavailability, Am. J. Clin. Nutr. 40, 1064–1070 (1984).
A. A. Minihane, T. E. Fox, and S. J. Fairweather-Tait, A continuous flow in vitro method to predict bioavailability of Fe from foods, in Bioavailability ’93. Nutritional, Chemical and Food Processing Implications Nutrient Availability, Proceedings, U. Schlemmer, ed., Bundesforschungs anstalt für Ernährung, Ettlingen, Germany, Pt. 2, pp. 175–179 (1993).
L. Shen, J. Luten, H. Robberecht, J. Bindels, and H. Deelstra, Modification of an in-vitro method for estimating the bioavailability of zinc and calcium from foods, Z. Lebensm. Unters. Forsch. 199, 442–445 (1994).
H. M. Edwards, Jr., The availability to chicks of zinc in various compounds and ores, J. Nutr. 69, 306–309 (1959).
D. A. Hill, A. R. Peo, Jr., A. J. Lewis, and J. D. Crenshaw, Zinc-amino acid complexes for swine, J. Anim. Sci. 63, 121–127 (1986).
J. W. Spears, Zinc methionine for ruminants: relative bioavailability of zinc in lambs and effects of growth and performance of growing heifers, J. Anim. Sci. 67, 835–843 (1989).
J. L. Pimentel, M. E. Cook, and J. L. Greger, Immune response of chicks fed various levels of zinc, Poult. Sci. 70, 947–954 (1991).
L. X. Rojas, L. R. McDowell, R. J. Cousins, F. G. Martin, N. S. Wilkinson, A. B. Johnson, et al., Interaction of different organic and inorganic zinc and copper sources fed to rats, J. Trace Element Med. Biol. 10, 139–144 (1996).
K. J. Wedekind and D. H. Baker, Zinc bioavailability in feed-grade zinc sources, J. Anim. Sci. 67(Suppl. 2), 126–132 (1989).
K. J. Wedekind and D. H. Baker, Zinc bioavailability in feed-grade sources of zinc, J. Anim. Sci. 68, 684–689 (1990).
K. J. Wedekind and D. H. Baker, Methodology for assessing zinc bioavailability: efficacy estimates for zinc-methionine, zinc sulphate and zinc oxide. J. Anim. Sci. 70, 178–187 (1992).
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Guillem, A., Alegría, A., Barberá, R. et al. In vitro dialyzability of zinc from different salts used in the supplementation of infant formulas. Biol Trace Elem Res 75, 11–19 (2000). https://doi.org/10.1385/BTER:75:1-3:11
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DOI: https://doi.org/10.1385/BTER:75:1-3:11