Abstract
The effectiveness and success of antitubercular therapy is mainly measured by identifying the organism in sputum. In certain patients, especially in geriatric patients, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness of antitubercular therapy, as the symptoms might be confused with the existing symptoms of ongoing diseases. Therefore, 60 diagnosed and randomly selected patients with tuberculosis were included into this study. The patients with other associated diseases likely to influence serum copper and zinc were not included in the study. The estimations of serum copper and zinc were done in healthy volunteers and in tubercular patients before the start of treatment and after 4 wk of antitubercular treatment. The average plasma concentration of serum copper and zinc in healthy volunteers were 102±20 μg/dL and 96±18 μg/dL respectively. In tuberculosis patients, serum copper and zinc levels were 123.65±9.98 μg/dL and 64.14±3.97 μg/dL, respectively, before the start of treatment, which came down to 116.23±4.27 μg/dL and 74.31±3.60 μg/dL, respectively, after 4 wk of antitubercular treatment.
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References
J. N. Bodgen, D. I. Lintz, M. M. Joselow, et al., Effect of pulmonary tuberculosis on blood concentration of copper and zinc, Am. J. Clin. Pathol., 67, 251–256 (1977).
R. K. Chandra, Trace elements and immune responses, in Trace Elements in the Nutrition of Children, R. K. Chandra, ed., Raven, New York (1989).
B. Cabrer, D. Bonfill, A. Grau, et al., Tuberculosis, pleural effusion and pleural effusion secondary to non specific bacterial infection: biochemical differential diagnosis, Med. Clin. 74, 89–92 (1980).
J. A. Halstead, and J. C. Smith, Jr., Plasma zinc in health and disease, Lancet 1, 322–324 (1970).
F. J. Underwood, Trace Elements in Human and Animal Nutrition, Academic, New York, pp. 68–73, 214–216 (1971).
W. R. Biesel, R. S. Pekarek, and R. W. Wannemacker, The impact of infectious disease on trace element metabolism of the host, in Trace Element Metabolism in Animals, W. G. Hoekstra, J. W. Suttie, and H. F. Ganther, eds., University Park Press, Baltimore, MD, pp. 217–240 (1974).
D. Morse, D. R. Brothwell, and P. Ucko, Tuberculosis in ancient Egypt, Lancet 3, 524–541 (1964).
B. Sharda and B. Bhandari, Serum zinc in childhood pulmonary tuberculosis, Indian Paediatr. 14, 195–196 (1997).
P. C. Khatri, B. D. Gupta, M. Miglani, and A. Jain, Serum zinc in pulmonary infection, Indian Paediatr. 18, 120–124 (1981)
B. K. Khanna, R. L. Kumar, P. K. Mukherjee, A. R. Chaudhary, and V. P. Kamboj, Plasma copper and zinc levels in pulmonary tuberculosis, Indian J. Tuberculosis 29, 179–181 (1982).
E. Karyadi, C. E. West, W. Schultink, et al., A double blind placebo-controlled study of vit A & zinc supplimentation in persons with tuberculosis in Indonesia. Effects on clinical response and nutritional status, Am. J. Clin. Nutri. 75, 720–27 (2002).
T. U. Ciftci, B. Ciftci, O. Yis, Y. Cunney, A. Bilgihan, and M. Ogretensoy Changes in serum selenium, copper and zinc level and copper/zinc ratio in patients with pulmonary tuberculosis during therapy, Biol. Trace Element Res. 95, 65–72 (2003).
X. Liu, L. Ding, Y. Wang, and Y. Yang, Determination of trace elements in serum of tuberculosis patients, Wei Sheng Yan Jiu 29, 395–396 (2000).
B. Hua, Clinical value of serum copper, zinc and copper zinc ratio in the differentiation of sarcoidosis from pulmonary tuberculosis and pulmonary carcinoma, Zhonghua Jie He He Hu Xi Za Zhi 12, 212–213 (1989).
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Mohan, G., Kulshreshtha, S. & Sharma, P. Zinc and copper in Indian patients of tuberculosis. Biol Trace Elem Res 111, 63–69 (2006). https://doi.org/10.1385/BTER:111:1:63
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DOI: https://doi.org/10.1385/BTER:111:1:63