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Oral and dental health care and anesthesia for persons with fibrodysplasia ossificans progressiva

  • Fibrodysplasia Ossificans Progressiva
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Abstract

Fibrodysplasia ossificans progressiva (FOP) is a devastating genetic disorder with profound oral and dental health care issues. Most patients with FOP eventually develop heterotopic ossification of the chewing muscles with resultant ankylosis of the temporom andibular joints. Preventive and restorative dental care, as well as endodontic, periodontic, and orthodontic care present therapeutic challenges to the dental practitioner, the anesthesiologist, and to the FOP patient throughout his or her life.

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References

  1. Connor JM, Evans DA. 1982 Fibrodysplasia ossificans progressiva (FOP): the clinical features and natural history of 34 patients. J Bone Joint Surg Br 64:76–83.

    PubMed  CAS  Google Scholar 

  2. Cohen RB, Hahn GV, Tabas J, et al. 1993 The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. J Bone Joint Surg 75-A:215–219.

    Google Scholar 

  3. Rocke DM, Zasloff M, Peeper J, Cohen RB, Kaplan FS. 1994 Age and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans progessiva. Clin Orthop Rel Res 301:243–248.

    Google Scholar 

  4. Kaplan FS, Shore EM, Connor JM. 2002 Fibrodysplasia ossificans progressiva (FOP). In: Royce PM, Steinmann B, eds. Connective Tissue and Its Heritable Disorders: Molecular, Genetic, and Medical Aspects, 2nd Ed. Wiley-Liss: John Wiley & Sons, New York, pp. 827–840.

    Google Scholar 

  5. Lanchoney TF, Cohen RB, Rocke DM, Zasloff MA, Kaplan FS. 1995 Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva. J Pediatrics 126:762–764.

    Article  CAS  Google Scholar 

  6. Connor JM, Evans, DA. 1982 Extra-articular ankylosis in fibrodysplasia ossificans progressiva. Br J Oral Surg 20:117–121.

    Article  PubMed  CAS  Google Scholar 

  7. Renton P, Parkin SF, Stamp TC. 1982 Abnormal temporomandibular joints in fibrodysplasia ossificans progressiva (FOP). Br J Oral Surg 20:31–38.

    Article  PubMed  CAS  Google Scholar 

  8. el-Labban NG, Hopper C, Barber P. 1995 Ultrastructural finding of vascular degeneration in fibrodysplasia ossificans progressiva (FOP). J Oral Pathol Med 24:125–129.

    Article  PubMed  CAS  Google Scholar 

  9. Luchetti W, Cohen RB, Hahn GV, et al. 1996. Severe restriction in jaw movement after route injection of local anesthetic in patients who have fibrodysplasia ossificans progressiva. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81:21–25.

    Article  PubMed  CAS  Google Scholar 

  10. Nussbaum BL, O'Hara I, Kaplan FS. 1996 Fibrodysplasia ossificans progressiva: report of a case with guidelines for pediatric dental and anesthetic management. J Dentistry Children 63:448–450.

    CAS  Google Scholar 

  11. Crofford LJ, Brahim JS, Zasloff, MA, Marini JC. 1990 Failure of surgery and isotretonoin to relieve jaw immobilization in fibrodysplasia ossificans progressiva (FOP): report of two cases. J Oral Maxillofac Surg 48:204–208.

    Article  PubMed  CAS  Google Scholar 

  12. Herford AS, Boyne PJ. 2003 Ankylosis of the jaw in a patient with fibrodysplasia ossificans progressiva. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:680–684.

    PubMed  Google Scholar 

  13. Webb MD, Wilson C. 1996 The use of intraosseous anesthesia in a patient with myositis ossificans progressiva. Spec Care Dentist 16:29–32.

    Article  PubMed  CAS  Google Scholar 

  14. Janoff HB, Zasloff MA, Kaplan FS. 1996 Submandibular swelling in patients with fibrodysplasia ossificans progressiva. Otolaryngol Head Neck Surg 114:599–604.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Burton L. Nussbaum DDS.

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Nussbaum, B.L., Grunwald, Z. & Kaplan, F.S. Oral and dental health care and anesthesia for persons with fibrodysplasia ossificans progressiva. Clinic Rev Bone Miner Metab 3, 239–242 (2005). https://doi.org/10.1385/BMM:3:3-4:239

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  • DOI: https://doi.org/10.1385/BMM:3:3-4:239

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