Abstract
The pathogenesis of autoimmune disease is still an enigma. Whereas the diverse clinical manifestations of many autoimmune diseases cannot be explained by the existence of autoantibodies, idiotypic dysregulation may provide an alternative explanation. Experimental models, serum level changes of pathogenic idiotypes during exacerbation and remission, and the increased expression of pathogenic idiotypes following common infections all support this notion. In this article we review experimental models of autoimmune disease induction (systemic lupus erythematosus, antiphospholipidsyn drome, Goodpasture's syndrome, autoimmune thyroiditis, and vasculitis) by manipulation of the idiotypic network and discuss the utilization of idiotypes for the immunotherapy of autoimmune diseases and other conditions that involve the immune system (e.g., atherosclerosis).
Similar content being viewed by others
References
Tomer, Y., and Shoenfeld, Y. (1991), G. Ital. Allergol. Immunol. Clin. 1, 3–15.
Shoenfeld, Y. and Isenberg, D., (1989) The Mosaic of Autoimmunity Elsevier, Amsterdam
Shoenfeld, Y., Kennedy, R. C. and Ferrone, S. (1997), Idiotypes In Medicine: Autoimmunity, Infection And Cancer, Elsevier, Amsterdam.
Buskila, D., Abu-Shakra, M., and Shoenfeld, Y. (1997), in Idiotypes in Medicine: Autoimmunity Infection and Cancer, Shoenfeld, Y., Kennedy, R. C., and Ferrone, S., eds., Elsevier, Amsterdam, pp. 75–88.
Baccala, R., Quang, T. V., Gilbert, M., Ternynck, T., and Avrameas, S. (1989), Proc. Natl. Acad. Sci. USA, 86, 4624–4628.
Marion, T. N., Bothwell, A. L. M., Briles, D. E., and Janeway, C. A. Jr. (1989), J. Immunol. 142, 4269–4272.
Blanco, F., Longhurst, T., Watts, R., Kalsi, J., Wiloch, H. W., Youinou, P., Latchman, D. S., and Isanberg, D. A. (1994), Lupus 3, 15–24.
Ehrenstein, M. R., Longhurst, C. M., Latchman, D. S., and Isenberg, D. A. (1994), J. Clin. Investig. 93, 1787–1797.
Ehrenstein, M. R., Hartley, B., Wilkinson, L. S., and Isenberg, D. A. (1994), J. Autoimmun. 7, 349–367.
Kalsi, J. K., Ravirajan, C. T., Wiloch-Winska, H., Blanco, F., Longhurst, C. M., Williams, W., Chapman, C., Hillson, J., Youinou, P., Latchman, D., et al. (1995), Lupus 4, 375–389.
Uner, A. H., Knupp, C. J., Tatum, A. H., and Gavalchin, J. (1994). J. Autoimmun., 7, 27–44.
Knupp, C. J., Uner, A. H., Tatum A. H., Kakanar, J. R., and Gavalchin, J. (1995), J. Autoimmun. 8, 367–380.
Kopchaliiska, D., Stamenova, M., Manolova, V., Kehavov, I., Dakovska, L., and Kyurkchiev, S. (1998), Clin. Immunol. Immunopathol. 87, 130–138.
Mendlovic, S., Brocke, S., Shoenfeld, Y., et al. (1988), Proc. Natl. Acad. Sci. USA 85, 2260–2264.
Blank, M., Mendlovic, S., Moses, E., et al. (1989), J. Autoimmun. 1, 683–691.
Blank, M., Krup, M., Mendlovic, S., et al. (1990), Scand. J. Immunol. 31, 45–52.
Rombach, E., Stetler, D. A., and Brown, J. C. (1992), Autoimmunity 13, 291–302.
Dang, H., Ogawa, N., Takei, M., et al. (1993), J. Immunol., 151, 7260.
Waisman, A., Ruiz, P. J., and Mozes, E. (1996), Lupus 5, 279–287.
Krause, I., Blank, M., and Shoenfeld, Y., (1996), Int. Arch. Allergy. Appl. Immunol. 111, 355–361.
Ziporen, L., Blank, M., and Shoenfeld, Y. (1997), Rheum. Dis. Clin. N. Am. 23, 99–117.
Blank, M., Cohen, J., Toder, V., et al. (1991) Proc. Natl. Acad. Sci. USA, 88, 3069–3073.
Bakimer, R., Fishman, P., Blank, M., et al. (1992), J. Clin. Investig. 89, 1558–1563.
Sthoeger, Z. M., Mozes, E., Tartakovsky, B., et al. (1993), Proc. Natl. Acad. Sci. USA 90, 6464–6467.
Yodfat, O., Blank, M., Krause, I., et al. (1996), Clin. Exp. Immunol. 78, 14–20.
Pierangeli, S. S., Xiao, W., Lui, W., et al. (1996). Circulation 1746–1751.
Shoenfeld, Y., Gilburd, B., Hojnic, M., et al. (1995) Hum. Antib. Hybrid 6, 122–128.
Tomer, Y., Gilburd, B., Sack, J., et al. (1996), Clin. Immunol. Immunopathol. 78, 180–187.
Blank, M., Tomer, Y., Stein, M., et al. (1995), Clin. Exp. Immunol. 102, 120–130.
Tomer, Y., Gilburd, B., Blank, M., et al. (1995), Arthritis Rheum 38, 1375–1381.
Damianovich, M., Gilburd, B., George, J., et al. (1996) J Immunol. 156, 4946–4951.
Levy, Y., Gilburd, B., George, J., Del Papa, N., Mallone, R., Damianovich, M., Blank, M., Radice, A., Renaudineau, Y., Youinou, P., Wiik, A., Malavasi, F., Meroni, P. L., and Shoenfeld, Y. (1998), Int. Immunol. 10, 861–868.
George, J., Harats, D., Gilburd, B, and Shoenfeld, Y. (1996), Immunol. Res. 15, 315–322.
George, J., Afek, A., Gilburd, B., et al. (1997), Lupus, 6, 723–729.
George, J., Afek, A., Gilburd, B., Blank, M., Levy, Y., Aron-Maor, A., Levkovitz, H., Shaish, A., Goldberg, I., Kopolovic, J., Harats, D., and Shoenfeld, Y. (1998), Circulation 98, 1108–1115.
George, J., Afek, A., Gilburd, B., Levkovitz, H., Shaish, A., Goldberg, I. Kopolovic, J., Wick, G., Shoenfeld, Y., and Harats, D. (1998), Atherosclerosis, 138, 147–152.
Shoenfeld, Y. (1994), FASEB J. 8, 1296–1301.
Spalter, S. H., Kaveri, S., and Kazatchkine, M. D. (1997), in Idiotypes in Medicine: Autoimmunity Infection and Cancer, Shoenfeld, Y., Kennedy, R. C., and Ferrone, S., eds., Elsevier, Amsterdam, pp. 217–226.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sherer, Y., Shoenfeld, Y. Idiotypic network dysregulation. Appl Biochem Biotechnol 83, 155–162 (2000). https://doi.org/10.1385/ABAB:83:1-3:155
Issue Date:
DOI: https://doi.org/10.1385/ABAB:83:1-3:155