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Applied Biochemistry and Biotechnology

, Volume 78, Issue 1–3, pp 401–407 | Cite as

Optimization of L-Lactic acid production from glucose by Rhizopus oryzae ATCC 52311

  • Ying Zhou
  • José M. Domínguez
  • Ningjun CaoEmail author
  • Jianxin Du
  • George T. Tsao
Article

Abstract

The effect of nutrients on L(+)-lactic acid production from glucose was investigated using Rhizopus oryzae ATCC 523 11. From the shake-flask experiments, the optimal medium composition was defined for improved lactic-acid production. In order to enhance lactic-acid production rate and product yield, controlled aeration in a bubble column was conducted under optimal conditions. Results showed a maximum lactic-acid production rate of 2.58 g/L/h was obtained with an initial glucose concentration of 94 g/L. Finallactic-acid concentration of 83 g/L was achieved after 32 h of fermentation with a weight of 0.88 glactic acid/g glucose consumed.

Index Entries

Bubble column lactic acid Rhizopus oryzae 

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Copyright information

© Humana Press Inc. 1999

Authors and Affiliations

  • Ying Zhou
    • 1
  • José M. Domínguez
    • 1
  • Ningjun Cao
    • 1
    Email author
  • Jianxin Du
    • 1
  • George T. Tsao
    • 1
  1. 1.Laboratory of Renewable Resources EngineeringPurdue UniversityWest Lafayette

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