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Applied Biochemistry and Biotechnology

, Volume 122, Issue 1–3, pp 639–652 | Cite as

Enhancing design of immobilized enzymatic microbioreactors using computational simulation

  • Robert BaileyEmail author
  • Frank Jones
  • Ben Fisher
  • Bill Elmore
Article

Abstract

In continuous-flow enzymatic microbioreactors, enzymes on the channel walls catalyze reaction(s) among feed chemicals, resulting in the production of some desirable material or the destruction of some undesirable material. Computational models of microbioreactors were developed using the CFD-ACE+ multiphysics simulation package. These models were validated via comparison with experimental data for the destruction of urea, catalyzed by urease. Similar models were then used to assess the impact of internal features on destruction efficiency. It was found that triangular features within the channels enhanced the destruction efficiency more than could be attributed to the increase in surface area alone.

Index Entries

Numerical modeling microreactor enzyme urea polydimethylsiloxane destruction efficiency 

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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  • Robert Bailey
    • 1
    Email author
  • Frank Jones
    • 1
  • Ben Fisher
    • 1
  • Bill Elmore
    • 2
  1. 1.Chemical, Environmental, and Mechanical EngineeringUniversity of Tennessee at ChattanoogaChattanooga
  2. 2.Chemical Engineering DepartmentLouisiana Tech UniversityReston

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