Abstract
Adsorption kinetics and equilibrium data of clavulanic acid, a β-lactam antibiotic, on ion-exchange resin Amberlite IRA 400 were utilized to carry out the modeling and simulation of a continuous adsorption process. These simulations allowed the estimation of yield, concentration, and purification factors of the process utilizing the product final concentration. Experimental runs of this process were carried out using the conditions pointed out by simulation studies. Comparison of the experimental results and those calculated by the proposed model showed that the model could describe very well the main features of the continuous process.
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Abbreviations
- C k :
-
CA concentration in the solution (g/L)
- C ik :
-
CA concentration inside the particles (g/L)
- C Sk :
-
CA concentration at particle surface (g/L)
- C Ek :
-
NaCl concentration (%)
- C Tk :
-
contaminant concentration (g/L)
- D efk :
-
effective diffusivity of CA (cm2/s)
- e :
-
difference between simulated and experimental data (%)
- F k :
-
flow rate of feeding (mL/min)
- F r :
-
flow rate of recycle (mL/min)
- K D :
-
Langmuir equilibrium constant (g/L)
- K Sk :
-
mass transfer coefficient (cm/s)
- k 1 :
-
intrinsic kinetic constant for adsorption stage (g/[L·min])
- k 2 :
-
intrinsic kinetic constant for adsorption stage (min−1)
- k 3 :
-
intrinsic kinetic constant for desorption stage (min−1)
- N :
-
number of points of collocation (−)
- q mk :
-
kinetic equilibrium parameter (gCA/gres)
- q k :
-
average amount of CA adsorbed in each stage (gCA/gres)
- q ik :
-
amount adsorbed in present particle along position r (gCA/gres)
- V k :
-
volume of present liquid phase (m/L)
- w j :
-
weights of Radau quadrature (Eqs. 13 and 14) or Gauss (Eq. 12)
- ε rk :
-
volume phase ratio, liquid to total phase volume (−)
- ε p :
-
porosity of resin (−)
- θ rk :
-
reactor residence time (min)
- θ sk :
-
solid residence time (min)
- k :
-
0=initial
- k :
-
1=first stage
- k :
-
2=second stage
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Almeida, R.M.R.G., Barboza, M. & Hokka, C.O. Continuous clavulanic acid adsorption process. Appl Biochem Biotechnol 108, 867–879 (2003). https://doi.org/10.1385/ABAB:108:1-3:867
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DOI: https://doi.org/10.1385/ABAB:108:1-3:867