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Applied Biochemistry and Biotechnology

, Volume 102, Issue 1–6, pp 119–128 | Cite as

Optimization of media by evolutionary algorithms for production of polyols

  • S. V. Patil
  • V. K. Jayaraman
  • B. D. Kulkarni
Article

Abstract

Biotransformation of sucrose-based medium to polyols has been reported for the first time using osmophilic yeast, Hansenula anomala. A new, real coded evolutionary algorithm was developed for optimization of fermentation medium in parallel shake-flask experiments. By iteratively employing the nature-inspired techniques of selection, crossover, and mutation for a fixed number of generations, the algorithm obtains the optimal values of important process variables, namely, inoculum size and sugar, yeast extract, urea, and MgSO4 concentrations. Maximum polyols yield of 76.43% has been achieved. The method is useful for reducing the overall development time to obtain an efficient fermentation process.

Index Entries

Media optimization polyols yield genetic algorithm 

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Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • S. V. Patil
    • 1
  • V. K. Jayaraman
    • 2
  • B. D. Kulkarni
    • 2
  1. 1.Department of Alcohol TechnologyVasantdada Sugar InstitutePuneIndia
  2. 2.National Chemical LaboratoryChemical Engineering DivisionPuneIndia

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