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Protection of myocardial mitochondria against oxidative damage by selenium-containing abzyme m4G3

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Abstract

Selenium-containing abzyme (m4G3) was prepared and its protection of myocardial mitochondria against oxidative damage was studied using the swelling of mitochondria, quantity of lipid peroxidation products, and change in cytochrome-c oxidase activity as a measure of mitochondrial damage. The results showed that m4G3 could inhibit mitochondrial damage caused by the hypoxanthine-xanthine oxidase system in vitro. Electronic spin resonance (ESR) studies demonstrated that m4G3 could decrease the amount of free radicals generated in the damage system.

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Authors and Affiliations

  1. National Laboratory of Enzyme Engineering, Jilin University, 130023, Changchun, China

    Dan-Hua Qi, Gui-Min Luo & Li Zhou

  2. Institute of Epidemic Diseases, Bethune Medical University, 130023, Changchun, China

    Tong-Shu Yang

Authors
  1. Dan-Hua Qi
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  2. Gui-Min Luo
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  3. Li Zhou
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  4. Tong-Shu Yang
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Correspondence to Gui-Min Luo.

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Qi, DH., Luo, GM., Zhou, L. et al. Protection of myocardial mitochondria against oxidative damage by selenium-containing abzyme m4G3. Appl Biochem Biotechnol 82, 167–173 (1999). https://doi.org/10.1385/ABAB:82:3:167

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  • DOI: https://doi.org/10.1385/ABAB:82:3:167

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