Background: Familial correlations, twin studies and adoption studies have all indicated that human obesity has a substantial genetic component. To date, obesity genes have only been identified using mouse models. Methods: In an attempt to identify human obesity genes large numbers of multigenerational families, in whom extreme obesity segregates, are currently being collected. Results and Conclusions: Relative risk estimates and models of genetic heterogeneity indicate that at least 500 affected sibling pairs will need to be collected to identify major genes.
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North, M., Jacobs, J.R., Murphy, L. et al. Identification of Genes Predisposing to Clinically Severe Obesity: An Approach. OBES SURG 5, 319–322 (1995). https://doi.org/10.1381/096089295765557719
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DOI: https://doi.org/10.1381/096089295765557719