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Direct Resolution of the Enantiomers of Betaxolol and Related Intermediates, and Its Application

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Abstract

An OJ-H chiral column has been used for direct resolution of the enantiomers of betaxolol and related intermediates in the preparation of (S)-betaxolol. The enantiomers can be excellently resolved (R S > 2) within 9.4 min with high peak symmetry. The enantiomers of some acetylated intermediates, which cannot be resolved on an OD-H column, can also be resolved. The method is simple and suitable for routine determination of ee values in the preparation of (S)-betaxolol.

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Acknowledgment

We acknowledge the National Natural Science Foundation of the PR China for financial support of this work (20572103).

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Authors and Affiliations

  1. Department of Chemistry, School of Pharmaceutical Sciences, New Drug Research and Development Center, Zhengzhou University, Zhengzhou, 450001, People’s Republic of China

    Yong-Hong Li, Li-Hua Huang, Shu-Sheng Zhang & Hong-Min Liu

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  1. Yong-Hong Li
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  2. Li-Hua Huang
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  3. Shu-Sheng Zhang
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Correspondence to Hong-Min Liu.

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Li, YH., Huang, LH., Zhang, SS. et al. Direct Resolution of the Enantiomers of Betaxolol and Related Intermediates, and Its Application. Chroma 71, 987–991 (2010). https://doi.org/10.1365/s10337-010-1615-9

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