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Chromatographia

, 70:1743 | Cite as

A Fast and Simple Screening Method for m-Nisoldipine and Its Related Substances by MEKC

  • De-Zhi Kong
  • Zhi-Fang Yuan
  • Xiao-Wei Zhang
  • Xiao-Na Sheng
  • Na Wang
  • Song-song Xing
  • Yu-Min Du
  • Lan-Tong Zhang
Full Short Communication

Abstract

A rapid and simple method has been developed and validated for the determination of m-nisoldipine and its five related substances using micellar electrokinetic capillary chromatography (MEKC). The key factors, including pH, buffer concentration and buffer additive, sodium dodecyl sulfate (SDS) concentration, applied voltage and temperature were systematically investigated in an uncoated fused silica capillary. The total analysis time was less than 9 min. The forced degradation products of m-nisoldipine, which were induced by hydrogen peroxide, acidic and basic conditions, heat and light, were also tested.

Keywords

Micellar electrokinetic capillary chromatography m-Nisoldipine Related substances 

Notes

Acknowledgments

The project was supported in part by the National Natural Science Foundation of China (No. 30840098) and Natural Science Foundation of Hebei Province (No. C 2008001073).

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Copyright information

© Vieweg+Teubner | GWV Fachverlage GmbH 2009

Authors and Affiliations

  • De-Zhi Kong
    • 1
  • Zhi-Fang Yuan
    • 1
  • Xiao-Wei Zhang
    • 2
  • Xiao-Na Sheng
    • 2
  • Na Wang
    • 1
  • Song-song Xing
    • 3
  • Yu-Min Du
    • 3
  • Lan-Tong Zhang
    • 1
  1. 1.Department of Pharmaceutical Analysis, School of PharmacyHebei Medical UniversityShijiazhuangChina
  2. 2.Department of Metabolic Regulation, Institute of Aging and AdaptationShinshu University Graduate School of MedicineNaganoJapan
  3. 3.Department of Pharmaceutical Chemistry, School of PharmacyHebei Medical UniversityShijiazhuangChina

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