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A Fast and Simple Screening Method for m-Nisoldipine and Its Related Substances by MEKC

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Abstract

A rapid and simple method has been developed and validated for the determination of m-nisoldipine and its five related substances using micellar electrokinetic capillary chromatography (MEKC). The key factors, including pH, buffer concentration and buffer additive, sodium dodecyl sulfate (SDS) concentration, applied voltage and temperature were systematically investigated in an uncoated fused silica capillary. The total analysis time was less than 9 min. The forced degradation products of m-nisoldipine, which were induced by hydrogen peroxide, acidic and basic conditions, heat and light, were also tested.

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References

  1. Yuan F, Wu Y, Nie H, Yan Y, Bao C, Chen Z, Du Y, Zhao J, Man D, Geng H CN93103759.X

  2. Chen ZM, Bao CH, Ma ZB, Yuan FY (2002) J HEB Med Univ 23:227–228

    CAS  Google Scholar 

  3. Gao YJ, Li YS, Fu SX (1990) Chin Pharmacol Bull 6:114–117

    Google Scholar 

  4. Gao YJ, Li YS, Fu SX (1990) Chin J Pharmacol Toxicol 4:21–25

    CAS  Google Scholar 

  5. Wu H, Zhang LT, Yuan ZF, Liu WN (2006) Chin J Pharm Anal 26:799–801

    CAS  Google Scholar 

  6. Marciniec B, Ogrodowczyk M (2006) Acta Pol Pharm 63:477–484

    Google Scholar 

  7. Agbaba D, Vucicevic K, Marinkovic V (2004) Chromatographia 60:223–227

    Article  CAS  Google Scholar 

  8. Marinkovic V, Agbaba D, Karljikovic-Rajic K, Comor J, Zivanov-Stakic D (2000) Farmaco 55:28–133

    Article  Google Scholar 

  9. Marinkovic VD, Agbaba D, Karljikovic-Rajic K, Vladimirov S, Nedeljkovic JM (2003) J Pharm Biomed Anal 32:929–935

    Article  CAS  Google Scholar 

  10. Jing XJ, Han XJ, Zhang LT, Li M (2008) Chin J Pharm 39:125–127

    CAS  Google Scholar 

  11. Álvarez-Lueje A, Naranjo L, Núñez-Vergara LJ, Squella JA (1998) J Pharm Biomed Anal 16:853–862

    Article  Google Scholar 

  12. Ikegaya H, Kobayashi M, Sakurada K, Takeichi H, Yoshida K, Iwase H (2002) Forensic Sci Int 130:25–28

    Article  CAS  Google Scholar 

  13. Wang H, Zhang L, Wang Q, Yuan Z, Li M (2006) J Chromatogr B 835:71–76

    Article  CAS  Google Scholar 

  14. Van Eeckhaut A, Detaevernier MR, Michotte Y (2004) J Pharm Biomed Anal 36:799–805

    Article  Google Scholar 

  15. Dang QX, Sun ZP, Ling DK (1992) J Chromatogr 603:259–266

    Article  CAS  Google Scholar 

  16. Gowsi K, Foley JP, Gale RJ (1990) Anal Chem 62:2714–2721

    Article  Google Scholar 

  17. Zukowski J, De BV, Berthod A (2002) J Chromatogr A 948:331–342

    Article  CAS  Google Scholar 

  18. Pan J, Zhang S, Yan L, Tai J, Xiao Q, Zou K, Zhou Y, Wu J (2008) J Chromatogr A 1185:117–129

    Article  CAS  Google Scholar 

  19. Őztekin N, Başkan S, Erim FB (2007) J Chromatogr B 850:488–492

    Article  Google Scholar 

  20. Tripodi VP, Lucangioli SE, Barbara CL, Rodríguez VG, Carducci CN (2001) Chromatographia 54:93–98

    Article  CAS  Google Scholar 

  21. Yang Y, Boysen RI, Hearn MT (2004) J Chromatogr A 1043:81–89

    Article  CAS  Google Scholar 

  22. Chen Y (2006) The technology and application of CE, 2nd Ed. Chemical Industry Press, Beijing

    Google Scholar 

Download references

Acknowledgments

The project was supported in part by the National Natural Science Foundation of China (No. 30840098) and Natural Science Foundation of Hebei Province (No. C 2008001073).

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Authors and Affiliations

  1. Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, China

    De-Zhi Kong, Zhi-Fang Yuan, Na Wang & Lan-Tong Zhang

  2. Department of Metabolic Regulation, Institute of Aging and Adaptation, Shinshu University Graduate School of Medicine, Nagano, Japan

    Xiao-Wei Zhang & Xiao-Na Sheng

  3. Department of Pharmaceutical Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, China

    Song-song Xing & Yu-Min Du

Authors
  1. De-Zhi Kong
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  2. Zhi-Fang Yuan
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  3. Xiao-Wei Zhang
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  4. Xiao-Na Sheng
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  5. Na Wang
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  6. Song-song Xing
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  7. Yu-Min Du
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  8. Lan-Tong Zhang
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Correspondence to Lan-Tong Zhang.

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Kong, DZ., Yuan, ZF., Zhang, XW. et al. A Fast and Simple Screening Method for m-Nisoldipine and Its Related Substances by MEKC. Chroma 70, 1743–1748 (2009). https://doi.org/10.1365/s10337-009-1384-5

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  • DOI: https://doi.org/10.1365/s10337-009-1384-5

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