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Matrix Solid-Phase Dispersion Extraction for Analysis of Cypermethrin Residue in Cows’ Milk

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Abstract

A method of extraction based on matrix solid-phase dispersion has been developed, optimized, and validated by chromatographic analysis of cypermethrin pesticide residues in samples of cows’ milk. Milk (0.25 g) was fortified with cypermethrin and blended with 1 g each of C18 (octadecylsilane) silica and Na2SO4 (anhydrous sodium sulfate), used to trap fats and water, respectively. The homogenized material was transferred to a commercial SPE cartridge containing 1 g activated Florisil with 5 mL acetonitrile. Cypermethrin was eluted under vacuum with 5 × 2 mL acetonitrile and the extract was concentrated to 1 mL and analyzed by gas chromatography–mass spectrometry. The limits of detection and quantification of the method were 0.025 and 0.08 mg kg−1, respectively.

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Acknowledgments

The authors are grateful to São Paulo State Research Foundation (FAPESP) for financial support of this research.

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Correspondence to Silvia Helena Govoni Brondi.

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Macedo, A.N., Nogueira, A.R.A. & Brondi, S.H.G. Matrix Solid-Phase Dispersion Extraction for Analysis of Cypermethrin Residue in Cows’ Milk. Chroma 69, 571–573 (2009). https://doi.org/10.1365/s10337-009-0953-y

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  • DOI: https://doi.org/10.1365/s10337-009-0953-y

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