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Chromatographia

, Volume 68, Issue 11–12, pp 1039–1044 | Cite as

A Glass/PDMS Hybrid Microfluidic Chip Embedded with Integrated Electrodes for Contactless Conductivity Detection

  • Ou-Lian Li
  • Yan-Li Tong
  • Zuan-Guang Chen
  • Cui Liu
  • Shen Zhao
  • Jin-Yuan Mo
Full Short Communication

Abstract

A new glass/PDMS hybrid chip for contactless conductivity detection is reported. This chip consists of a glass substrate with microchannels and a PDMS cover sheet embedded with a small integrated electrode plate. In the region of detection, electrodes are insulated from the microchannel by a formed PDMS membrane about 100 μm in thickness. Without any modification, this glass/PDMS chip is suitable for contactless conductivity detection with good properties, such as excellent heat-dissipation, stable electroosmotic flow, high separation efficiency, satisfactory sensitivity, simple construction and high degree of integration. Its feasibility and performance had been demonstrated by analyzing inorganic ions and amino acids in mixtures, and alkaloids in traditional Chinese medicine. The limits of detection reached micromole per liter (μmol L−1) levels. This microchip could be promising for mass production due to its stability, reproducibility, ease of fabrication and low cost.

Keywords

Contactless conductivity detection Glass/PDMS Hybrid microchips 

Notes

Acknowledgments

The authors gratefully acknowledge financial support from the National Natural Science Foundation of China (NSFC, Grant Nos. 20375049, 20575080, and 20727006) and engineer Hexian Situ and Mr Chunlin Chen for their help in revising this paper.

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Copyright information

© Vieweg+Teubner | GWV Fachverlage GmbH 2008

Authors and Affiliations

  • Ou-Lian Li
    • 1
  • Yan-Li Tong
    • 1
  • Zuan-Guang Chen
    • 1
  • Cui Liu
    • 1
  • Shen Zhao
    • 2
  • Jin-Yuan Mo
    • 2
  1. 1.School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhouChina
  2. 2.School of Chemistry and Chemical EngineeringSun Yat-sen UniversityGuangzhouChina

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