Sensitive Determination of Cyanide in Cigarette Smoke by Capillary GC with a MicroECD
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A sensitive method using capillary gas chromatography coupled with a micro electron capture detector (μECD) has been developed for the determination of cyanide in cigarette smoke. The procedure is based upon the conversion of cyanide to cyanogen chloride by chloramine-T. Cyanogen chloride, dissolved in n-hexane, was analyzed by GC–μECD. Under optimum conditions, the detector response was linear from 25.0 ng mL−1 to 15.0 μg mL−1 with relative standard deviation between 0.07 and 3.30%. Recovery ranged from 86.0 to 116.0%. The method was shown to be precise, accurate and linear over the range of concentration of analytes.
KeywordsGas chromatography Capillary column Cyanide in cigarette smoke
This work was supported by the Technology Center of Hefei Cigarette Factory, China.
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