Skip to main content

Advertisement

SpringerLink
Log in

Modelisation of the Association Mechanism of a Series of Huperzine Derivatives Used for Alzheimer Disease with Human Serum Albumin: Effect of the Magnesium Cation

  • Published:
Chromatographia Aims and scope Submit manuscript

Abstract

The role of the Mg2+ cation on huperzine molecule binding (drugs used for Alzheimer disease) on human serum albumin (HSA) was studied by affinity chromatography. The thermodynamic data corresponding to this binding were determined for a wide range of Mg2+ concentrations (x). For each solute, the huperzine binding on HSA was divided into two Mg2+ concentration regions. For a low x value, below x c (1.2 mM), the binding decrease with x. For x above x c the hydrophobic effect and van der Waals interactions between the huperzine molecule and the HSA implied a decrease in its binding. These results showed that for patients with Alzheimer disease, an Mg2+ supplementation during treatment with these huperzine molecules can increase the active pharmacological molecule concentration.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Debosby ST, Scheff SW (1990) Ann Neurol 27:457

    Google Scholar 

  • Terry RD, Masliah E (1991) Ann Neurol 30:572

    CAS  Google Scholar 

  • Candy JW, Perry RH, Perry EK, Irving D, Blessed G, Fairbairn AF (1983) J Neurol Sci 59:277

    CAS  Google Scholar 

  • Giacobini E (2000) Cholinesterase inhibitors: from the calabar bean to Alzheimer therapy. In: Giacobini E ed, Cholinesterases and Cholinesterase Inhibitors. Martin Dunitz, Thonex-Geneva, pp. 181

  • Tang XC, He XC, Bai DL (1999) Drugs Future 24:647

    CAS  Google Scholar 

  • Giacobini E (1994) Cholinomimatic therapy of Alzheimer disease: does it slow down deterioration? In: Racagni G, Brunello N, Langer SZ (eds) Recent Advances in the Treatment of Neurodegenerative Disorders and Congnitive Dysfunction. International Academy Biomedical Drug Research 7(23): 51–57

    Google Scholar 

  • Irizarry MC, Growdon W, Gomez-Isla T, Newell K, George JM, Clayton DF, Hyman BT (1998) J Exp Neurol 57:334

    Article  CAS  Google Scholar 

  • Khale PJ, Haass C, Kretschmar HA, Neumann M, (2002) J Neurochem 82:449

    Google Scholar 

  • Kruger R, Muller T, Riess O (2000) J Neural Transm 107:31

    CAS  Google Scholar 

  • Lucking CB, Brice A (2000) Cell Mol Life Sci 57:1894

    CAS  Google Scholar 

  • Spilantini MG, Schmidt ML, Lee VMY, Trojanowski JO, Jakes R, Goedert M (1997) Nature 388:839

    Article  CAS  PubMed  Google Scholar 

  • Spilantini MG, Growther, RA, Jakes R, Hasegawa M, Goedert M (1998) Proc Natl Acad Sci 95:6469

    Article  CAS  PubMed  Google Scholar 

  • Takeda A, Hashimoto M, Mallory M, Sundsumo M, Hioner W, Hansen L, Masliah, E (1998) Am J Pathol 152:367

    CAS  Google Scholar 

  • Wirdefelt K, Bogdanovic N, Westerberg L, Payami H, Schalling M, Murdoch G (2001) Mol Brain Res 92:58

    Google Scholar 

  • Liou HH, Tsai MC, Chen CJ (1997) Neurology 48:1583

    CAS  PubMed  Google Scholar 

  • Marker K, Logroscino G, Alfaro B (1998) Neurology 50:279

    CAS  PubMed  Google Scholar 

  • Morano A, Jimenez FJ, Molina JA, Antolin MA (1994) Acta Neurol Scand 89:164

    Article  CAS  PubMed  Google Scholar 

  • Gorell JM, Johnson CC, Rybicki BA, Peterson EL, Richardson RJ (1998) Neurology 50:1346

    CAS  PubMed  Google Scholar 

  • Semchuk KM, Love EL, Lee RG (1993) Neurology 43:1173

    CAS  PubMed  Google Scholar 

  • Fall PA, Fredrikson M, Axelson O, Cranerus AK (1999) Mov Disord 14:28

    Article  CAS  PubMed  Google Scholar 

  • Gorell JM, Johnson CC, Rybicki BA (1997) Neurology 48:650

    CAS  Google Scholar 

  • Kuhn W, Winkel R, Woitalla D, Meves S, Przuntzk H, Muller T (1998) Neurology 50:1885

    CAS  Google Scholar 

  • Golts N, Snyder H, Frasier M, Theisler C, Choi P, Wolozin B (2002) J Biol Chem 16:116

    Google Scholar 

  • Durlach J (1990) Magnesium Res 3:217

    CAS  Google Scholar 

  • Müller WE, Wollert U (1979) Pharmacology 19:59

    Article  Google Scholar 

  • Vidal-Madjar C, Jaulmes A, Racine M, Sebille B (1998) J Chromatogr 458:13

    Google Scholar 

  • Nakano NI, Shimamori Y, Yamaguchi S (1980) J Chromatogr 188:347

    CAS  Google Scholar 

  • Loun B, Hage DS (1994) Anal Chem 66:3814

    CAS  Google Scholar 

  • Loun B, Hage DS (1992) J Chromatogr 579:225

    CAS  Google Scholar 

  • Andre C, Jacquot Y, Truong TT, Thomassin M, Robert JF, Guillaume YC (2003) J Chromatogr B 796:267

    CAS  Google Scholar 

  • Andre C, Berthelot A, Robert JF, Thomassin M, Guillaume YC (2003) J Pharm Biomed 33:911

    CAS  Google Scholar 

  • Tanford C (1973) The hydrophobic effect. Wiley, New York

  • Melander W, Campbell DE, Horvath C, (1978) J Chromatogr Sci 158:215

    CAS  Google Scholar 

  • Van Oss CJ (1994) Interfacial Forces in Aqueous Media. Marcel Dekker, New York

  • Guillaume YC, Peyrin E, Berthelot A (1999) J Chromatogr B 728:167

    CAS  Google Scholar 

  • Guillaume YC, Guinchard C, Robert JF, Berthelot A (2000) Chromatographia 52:575

    CAS  Google Scholar 

  • Bal W, Christodoulou J, Sadler PJ, Tucker A (1998) J Inorg Biochem 70:33

    CAS  Google Scholar 

  • Bender KI, Lutsevich AN (1983) Formakol Toksikol 46:59

    CAS  Google Scholar 

  • Krug RR, Hunter WG, Gieger RA J Phys Chem 80:2335

  • Peyrin E, Guillaume YC, Guinchard C (1998) Anal Chem 70:608

    Google Scholar 

  • André C, Guillaume YC (2004) Chromatographia 59:429

    Google Scholar 

  • Peter A, Torok G, Armstrong DW, Toth G, Tourwé D (1998) J Chromatogr A 828:177

    CAS  Google Scholar 

  • Ranatunga R, Vitha M, Carr PW (2002) J Chromatogr A 946:47

    CAS  Google Scholar 

  • Li J, Carr PW (1994) J Chromatogr A 670:105

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Equipe des Sciences Séparatives et Biopharmaceutiques (2SB/EA482), Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon cedex, France

    M. Morel, M. Thomassin, Y. C. Guillaume & C. André

  2. Equipe Optimisation du Métabolisme Cellulaire (OMC), Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon cedex, France

    A. Berthelot

Authors
  1. M. Morel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Thomassin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Berthelot
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. C. Guillaume
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. André
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Y. C. Guillaume.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morel, M., Thomassin, M., Berthelot, A. et al. Modelisation of the Association Mechanism of a Series of Huperzine Derivatives Used for Alzheimer Disease with Human Serum Albumin: Effect of the Magnesium Cation. Chroma 61, 253–258 (2005). https://doi.org/10.1365/s10337-005-0498-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1365/s10337-005-0498-7

Keywords

Search

Navigation