, Volume 60, Issue 5–6, pp 299–304 | Cite as

Evaluation of the Linear-Elution-Strength Model for the Prediction of Retention and Selectivity in Isothermal Gas Chromatography

  • M. I. Nawas
  • C. F. Poole


Linear-elution strength theory and temperature-programmed gas chromatography is evaluated as a rapid method for predicting isothermal retention factors and column selectivity. Retention times for a wide range of compounds are determined at the program rates of 3 and 12 °C/min for the temperature range 60 to 160 °C on three open-tubular columns (DB-1701, DB-210 and EC-Wax) and used to predict isothermal retention factors for each column over the temperature range 60 to 140 °C. The temperature-program predicted isothermal retention factors are compared with experimental values using linear regression and the solvation parameter model. It is shown that isothermal retention factors predicted by the linear-elution-strength model only approximately represents the experimental data. The model fails to predict the slight curvature that exists in most plots of the experimental retention factor (log k) as a function of temperature. In addition, regression of the temperature-program predicted isothermal retention factors against the experimental values indicates that the slopes and intercepts deviate significantly from their target values of one and zero, respectively, in a manner which is temperature dependent. The temperature-program predicted isothermal retention factors result in system constants for the solvation parameter model that are different to those obtained from the experimental retention factors. These results are interpreted as indicating that linear-elution-strength theory predicts retention factors that fail to accurately model stationary phase interactions over a wide temperature range. It is concluded that temperature-program methods using linear-elution-strength theory are unsuitable for constructing system maps for isothermal separations.


Gas chromatography Temperature programming Linear-elution-strength model Solvation parameter model 


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  1. Poole CF (2003) The Essence of Chromatography. Elsevier, AmsterdamGoogle Scholar
  2. Harris WE, Habgood HW (1967) Programmed Temperature Gas Chromatography. Wiley, New YorkGoogle Scholar
  3. Gonzalez FR, Nardillo AM (1999) J Chromatogr A 842:29–49CrossRefGoogle Scholar
  4. Al-Bajjari TI, Levent S, Taylor DR (1994) J Chromatogr 683:377–387CrossRefGoogle Scholar
  5. Dose EV (1987) Anal Chem 59:2420–2423Google Scholar
  6. Vezzani S, Moretti P, Costello G (1997) J Chromatogr A 767:115–125CrossRefGoogle Scholar
  7. Snijders H, Janssen H-G, Cramers C (1995) J Chromatogr A 718:339–356CrossRefGoogle Scholar
  8. Bautz DE, Dolan JW, Raddatz WD, Snyder LR (1990) Anal Chem 62:1560–1567PubMedGoogle Scholar
  9. Bautz DE, Doland JW, Snyder LR (1991) J Chromatogr 541:1–19CrossRefGoogle Scholar
  10. Jayatilaka A, Poole CF (1993) J Chromatogr 617:19–27CrossRefPubMedGoogle Scholar
  11. Blumberg LM, Klee MS (2001) J Chromatogr 918:113–120CrossRefGoogle Scholar
  12. Chen JP, Liang XM, Zhang Q, Zhang LF (2001) Chromatographia 53:539–547Google Scholar
  13. Chen JP, Liang XM, Zhang Q, Zhang LF (2001) Chromatographia 53:548–552Google Scholar
  14. Abraham MH, Poole CF, Poole SK (1999) J Chromatogr A 842:79–114CrossRefGoogle Scholar
  15. Poole CF, Poole SK (2002) J Chromatogr A 965:263–299CrossRefPubMedGoogle Scholar
  16. Poole CF, Li Q, Kiridena W, Koziol WW (2001) J Chromatogr A 912:107–117CrossRefPubMedGoogle Scholar
  17. Poole CF, Kiridena W, Nawas MI, Koziol WW (2002) J Sep Sci 25:749–759CrossRefGoogle Scholar
  18. Kiridena W, Poole CF, Koziol WW (2002) Analyst 127:1608–1613CrossRefPubMedGoogle Scholar
  19. Kiridena W, Poole CF, Nawas MI, Koziol WW (2003) J Sep Sci 26:1111–1118CrossRefGoogle Scholar
  20. Nawas MI, Poole CF (2004) J Chromatogr A 1023:113–121Google Scholar

Copyright information

© Friedr. Vieweg&Sohn/GWV Fachverlage GmbH 2004

Authors and Affiliations

  1. 1.Department of ChemistryWayne State UniversityDetroitUSA

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