Chinese Science Bulletin

, Volume 49, Issue 24, pp 2640–2643 | Cite as

The character of EBNA1 gene variation in Cantonese and its association with nasopharyngeal carcinoma

  • Shijuan Mai
  • Xiaoshi Zhang
  • Dajiang Li
  • Guoping Shen
  • Juhong Jiang
  • Ruhua Zhang
  • Xingjuan Yu
  • Shiping Chen
  • Yixin Zeng
Brief Communications
  • 16 Downloads

Keywords

Nasopharyngeal Carcinoma Peripheral Blood Cell Healthy Carrier Genesis Potential Nasopharyngeal Epithelial Cell 

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References

  1. 1.
    Bhatia, K., Raj, A., Guitierrez, M. I. et al., Variation in the sequence of Epstein Barr virus nuclear antigen 1 in normal peripheral blood lymphocytes and in Burkitt’s lymphomas, Oncogene, 1996, 13: 177–181.PubMedGoogle Scholar
  2. 2.
    Zhang, X. S., Wang, H. H., Hu, L. F. et al., V-val subtype of Epstein-Barr virus nuclear antigen 1 preferentially exists in biopsies of nasopharyngeal carcinoma, Cancer Lett., 2004, 211(1): 11–18.PubMedCrossRefGoogle Scholar
  3. 3.
    Wang, W. Y., Chien, Y. C., Jan, J. S. et al., Consistent sequence variation of Epstein-Barr virus nuclear antigen 1 in primary tumor and peripheral blood cells of patients with nasopharyngeal carcinoma, Clin. Cancer Res., 2002, 8: 2586–2590.PubMedGoogle Scholar
  4. 4.
    Sandvej, K., Zhou, X. G., Hamilton-Dutoit, S., EBNA-1 sequence variation in Danish and Chinese EBV-associated tumors: Evidence for geographical polymorphism but not for tumour-specific subtype restriction, J. Pathol., 2000, 191: 127–131.PubMedCrossRefGoogle Scholar
  5. 5.
    Chen, H. K., Feng, B. J., Liang, H. et al., The susceptibility gene for familial nasopharyngeal carcinoma is mapped on chromosome 4p11–p14 by haplotype analyses, Chinese Science Bulletin, 2003, 48(21): 2327–2330.CrossRefGoogle Scholar
  6. 6.
    Gutierrez, M. I., Raj, A., Spangler, G. et al., Sequence variations in EBNA-1 may dictate restriction of tissue distribution of Epstein-Barr virus in normal and tumour cells, J. Gen. Virol., 1997, 78: 1663–1670.PubMedGoogle Scholar
  7. 7.
    Wang, J. T., Sheeng, T. S., Su, I. J. et al., EBNA1 sequence variations reflect active EBV replication and disease status or quiescent latency in lymphocytes, J. Med. Virol., 2003, 69: 417–425.PubMedCrossRefGoogle Scholar
  8. 8.
    Wu, H., Kapoor, P., Frappier, L., Separation of the DNA replication, segregation, and transcriptional activation functions of Epstein-Barr nuclear antigen 1, J. Virol., 2002, 76(5): 2480–2490.PubMedCrossRefGoogle Scholar
  9. 9.
    Yin, Y., Manoury, B., Fahraeus, R., Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1, Science, 2003, 301: 1371–1374.PubMedCrossRefGoogle Scholar

Copyright information

© Science in China Press 2004

Authors and Affiliations

  • Shijuan Mai
    • 1
  • Xiaoshi Zhang
    • 1
  • Dajiang Li
    • 1
  • Guoping Shen
    • 1
  • Juhong Jiang
    • 1
  • Ruhua Zhang
    • 1
  • Xingjuan Yu
    • 1
  • Shiping Chen
    • 1
  • Yixin Zeng
    • 1
  1. 1.Department of Experimental Research, Cancer CenterSun Yat-sen UniversityGuangzhouChina

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