Time resolve study on isopropyl-ether porphyrindiol
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A novel fat-soluble porphyrin derivative—isopropyl-ether porphyrindiol (IPEP) has been investigated using the nanosecond laser photolysis and pulse radiolysis. In acetonitrile, IPEP-excited triplet state shows two relative absorption areas peaking at 320 and 430 nm, molar extinction coefficients by energy transfer method (in benzene solution) are proved to be ε (315) = 1.07}105, ε (450)=3.3}104 L3 · mo-1 · cm-1 and the excited triplet state quantum yield by comparative method is 0.18. Laser photolysis of IPEP in dGMP-containing solution shows that the triplet state cannot excite/oxidize dGMP via the energy/electron transfer process.
Keywordslaser photolysis pulse radiolysis excited triplet state photodynamic therapy isopropyl- ether porphyrindiol
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