Abstract
An inclusion complex (1) has been prepared by β-cyclodextrin with α-aminopyridine. The result of X-ray crystallographic analyses showed that the α-aminopyridine molecules in the β-cyclodextrin cavities possess two opposite orientations, i.e. the amine group of α-aminopyridine pointing to the primary side (1a, occupancy: 41.2%) or the secondary side (1b, occupancy: 58.8%) of β-cyclodextrin, forming two scalelike supramolecular aggregations. The studies of 2D NMR and circular dichroism spectra indicated that the α-aminopyridine molecule is deeply embedded in the β-cyclodextrin cavity to form host-guest inclusion complex, showing a circular dichroism spectrum induced by the chiral cavity of cyclodextrin. The results obtained are helpful for understanding the molecular recognition and aggregation mechanism between the host and guest.
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Yanli, Z., Yu, L. Self-assembly behavior of inclusion complex formed by β-cyclodextrin with α-aminopyridine. Sc. China Ser. B-Chem. 47, 200–205 (2004). https://doi.org/10.1360/03yb0169
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DOI: https://doi.org/10.1360/03yb0169