Science in China Series B: Chemistry

, Volume 47, Issue 3, pp 200–205 | Cite as

Self-assembly behavior of inclusion complex formed by β-cyclodextrin with α-aminopyridine

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Abstract

An inclusion complex (1) has been prepared by β-cyclodextrin with α-aminopyridine. The result of X-ray crystallographic analyses showed that the α-aminopyridine molecules in the β-cyclodextrin cavities possess two opposite orientations, i.e. the amine group of α-aminopyridine pointing to the primary side (1a, occupancy: 41.2%) or the secondary side (1b, occupancy: 58.8%) of β-cyclodextrin, forming two scalelike supramolecular aggregations. The studies of 2D NMR and circular dichroism spectra indicated that the α-aminopyridine molecule is deeply embedded in the β-cyclodextrin cavity to form host-guest inclusion complex, showing a circular dichroism spectrum induced by the chiral cavity of cyclodextrin. The results obtained are helpful for understanding the molecular recognition and aggregation mechanism between the host and guest.

Keywords

aggregation crystal structure cyclodextrin hydrogen bonds inclusion complex 

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Copyright information

© Science in China Press 2004

Authors and Affiliations

  1. 1.Department of Chemistry, State Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjinChina

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