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Science in China Series B: Chemistry

, Volume 46, Issue 4, pp 371–378 | Cite as

Novel ultrasound contrast agents

—Biodegradable poly(lactic acid) microcapsules
  • Wang Shenguo 
  • Wenjin Cui
  • Guangming Li
  • Qing Cai
  • Guang Zhi
  • Yuying Zhao
  • Bo Yang
  • Yong Xu
Article
  • 32 Downloads

Abstract

As a novel ultrasound diagnostic contrast agent, the preparation, characterization and ultrasound imaging in the body of dog about poly(lactic acid) (PLLA) microcapsules have been studied. The behavior of this kind of contrast agent in the microcirculation was also investigated. Prepared by (water/oil/water) emulsion-solvent evaporation protocol, the PLLA microcapsules with hollow structure can enhance the ultrasound image both in vitro and in vivo, and the enduring time can last as long as 3 h. The microcirculation examination shows that the PLLA microcapsules with a diameter ranging from 2 to 8 μm could pass through the pulmonary capillaries without retention. All the results prove the PLLA microcapsules for potential use for the clinical application.

Keywords

poly(lactic acid) microcapsules contrast agent ultrasound diagnosis blood filters 

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Copyright information

© Science in China Press 2003

Authors and Affiliations

  • Wang Shenguo 
    • 1
  • Wenjin Cui
    • 1
  • Guangming Li
    • 1
  • Qing Cai
    • 1
  • Guang Zhi
    • 2
  • Yuying Zhao
    • 2
  • Bo Yang
    • 2
  • Yong Xu
    • 2
  1. 1.Institute of ChemistryChinese Academy of SciencesBeijingChina
  2. 2.General Hospital of People’s Liberation ArmyBeijingChina

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