Chinese Science Bulletin

, Volume 47, Issue 17, pp 1415–1421 | Cite as

Strategy against micrometastasis of epithelial cancer: Detection and elimination

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Abstract

Tumor metastasis is generally agreed to be the major cause of cancer death. Over the last few years, studies of new diagnosis techniques and tumor immunotherapy have made great progress. Recent clinical studies on the occult metastases of breast, lung and colorectal cancer all suggested that the detection of micrometastases in bone marrow is prognostically important and provides substantial evidence of tumor dissemination. On the other hand, two kinds of the mAb-based immunotherapy have been approved for the treatment against epithelial cancer. Monoclonal antibody (mAb) 17-1A for colorectal carcinomas and mAb herceptin for breast cancer both have produced good curative effects. Potential therapeutics based on some antibodies with prominent antitumor activity also has shown obvious clinical effect. These studies indicate that detection of micrometastasis in circulatory system and immunotherapy by eliminating metastatic malignant cells suggested a new strategy against the metastatic cancer.

Keywords

tumor micrometastasis detection elimination immunotherapy mAb 

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Copyright information

© Science in China Press 2002

Authors and Affiliations

  1. 1.Laboratory of Immunology, Research Centre for Medical Science and Department of BiologyTsinghua University, Protein Science Laboratory of MOEBeijingChina

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