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Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose

  • Toshio Ariyasu
  • Shuji Matsumoto
  • Fumiyo Kyono
  • Toshiharu Hanaya
  • Shigeyuki Arai
  • Masao Ikeda
  • Masashi Kurimoto
Articles Cell and Tissue Models

Summary

Recently, a sweet taste receptor family, the T1R family, that recognizes some carbohydrates including sucrose was identified. Although the T1R3 molecule is known to participate in heterodimers that are used as sweet- and umamitasting receptors, there is no evidence that T1R3 alone recognizes similar ligands. We demonstrate for the first time that the candidate sweet taste receptor T1R3 is essential for the recognition and response to the disaccharide trehalose. Our system is a valuable tool not only for understanding the relationship between sweeteners and their receptors but also for exploring the diversities of their receptors, resulting in the design of new high-potency sweeteners.

Key words

T1Rs sweetener carbohydrates intracellular calcium G protein-coupled receptors 

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Copyright information

© Society for In Vitro Biology 2003

Authors and Affiliations

  • Toshio Ariyasu
    • 1
  • Shuji Matsumoto
    • 1
  • Fumiyo Kyono
    • 1
  • Toshiharu Hanaya
    • 1
  • Shigeyuki Arai
    • 1
  • Masao Ikeda
    • 1
  • Masashi Kurimoto
    • 1
  1. 1.Fujisaki InstituteHayashibara Biochemical Laboratories, Inc.OkayamaJapan

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