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Evidence-based prevention (EBP): A review of cytochrome P450 expression in the bronchial epithelium and new approach to lung cancer prevention

  • Review Article
  • Published:
Environmental Health and Preventive Medicine Aims and scope

Abstract

The number of fatalities in Japan attributable to lung cancer exceeded 50000 in 2001. It is socially desirable that various markers, which can be utilized for the prevention of lung cancer, be established. We believe that smoking or exposure to carcinogens in air induces mutations in bronchial and alveolar epithelia, leading to the development of lung cancer. It would be useful to have markers of individual differences in susceptibility to chemical carcinogen-induced lung cancer 1) to identify genetic polymorphisms of enzymes metabolizing chemical carcinogens and 2) to investigate the expression of enzymes metabolizing chemical carcinogens. In this paper, we review CYP expression in the bronchial epithelium. CYP1, CYP2 and CYP3 are expressed in the bronchial epithelium. We also show the relationship between the genetic polymorphisms of cytochrome P450 (CYP) and a person’s susceptibility to chemical carcinogen-induced lung cancer. We demonstrate the relationship between cigarette consumption and the CYP expression profile in the bronchial epithelium. To maintain and promote public health, we must apply evidence, such as CYP polymorphisms and CYP profiles to disease prevention and also to aggressively advance evidence-based prevention (EBP) of lung cancer.

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Abbreviations

CYP:

cytochrome P450

SNP:

single-nucleotide polymorphism

EBP:

evidence-based prevention

References

  1. Uramoto H, Nakanishi R, Fujino Y, Imoto H, Takenoyama M, Yoshimatsu T, et al. Prediction of pulmonary complications after a lobectomy in patients with non-small cell lung cancer. Thorax. 2001; 56: 59–61.

    Article  PubMed  CAS  Google Scholar 

  2. Osaki T, Mitsudomi T, Oyama T, Nakanishi R, Yasumoto K. Serum level and tissue expression of c-erbB-2 protein in lung adenocarcinoma. Chest. 1995; 108: 157–162.

    Article  PubMed  CAS  Google Scholar 

  3. Gu CD, Osaki T, Oyama T, Inoue M, Kodate M, Dobashi K, et al. Detection of micrometastatic tumor cells in pN0 lymph nodes of patients with completely resected nonsmall cell lung cancer; Impact on recurrence and survival. Ann Surg. 2001; 233: 133–139.

    Google Scholar 

  4. Osaki T, Oyama T, Inoue M, Gu CD, Kodate M, Aikawa M, et al. Molecular biological markers and micrometastasis in reseeted non-small-cell lung cancer. Prognostic implications. Jpn J Thorac Cardiovasc Surg. 2001; 49: 545–551.

    Article  PubMed  CAS  Google Scholar 

  5. Osaki T, Ovama T, Gu CD, Yamashita T, So T, Takenoyama M, et al. Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage 1 non-small-cell lung cancer. J Clin Oncol. 2002; 20: 2930–2936.

    Article  PubMed  Google Scholar 

  6. Oyma T, Kawamoto T, Matsuno M, Osaki T, Matsumoto A, Isse T, et al. A case-case study comparing the usefulness of serum trace elements (Cu, Zn and Se) and tumor markers (CEA, SCC and SLX) in non-small cell lung cancer patients. Anticancer Res. 2003; 23: 605–612.

    Google Scholar 

  7. Gu CD, Oyama T, Osaki T, Li J, Takenoyama M, Izumi H, et al. Low expression of polypeptide GalNac N-acetylgalactosaminyl transferase-3 in lung adenocarcinoma: Impact on poor prognosis and early recurence. Br J Cancer. 2004; 90: 436–442.

    Article  PubMed  CAS  Google Scholar 

  8. Uramoto H, Sugio K, Oyama T, Nakata S, Ono K, Morita M, et al. Expression of delta Np73 predicts poor prognosis in lung cancer. Clin Cancer Res. 2004; 10: 6905–6911.

    Article  PubMed  CAS  Google Scholar 

  9. Iwata T, Uramoto H, Sugio K, Fujino Y, Oyama T, Nakata S, et al. A lack of prognostic significance regarding DeltaNp63 immunoreactivity in lung cancer. Lung Cancer. 2005; 50: 67–73.

    Article  PubMed  Google Scholar 

  10. Oyama T, Osaki T, Baba T, Nagata Y, Mizukami M, So T, et al. Molecular genetic tumor markers in non-small cell lung cancer. Anticancer Res. 2005; 25: 1193–1196.

    PubMed  CAS  Google Scholar 

  11. Uramoto H, Sugio K, Oyama T, Nakata S, Ono K, Yoshimastu T, et al. Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance. Lung Cancer. 2005; 49: 55–62.

    Article  PubMed  Google Scholar 

  12. Uramoto H, Sugio K, Oyama T, Ono K, Sugaya M, Yoshimatsu T, et al. Epidermal growth factor receptor mutations are associated with gefitinib sensitivity in non-small cell lung cancer in Japanese. Lung Cancer. 2005 (in press).

  13. Yoshimatsu T, Uramoto H, Oyama T, Yashima Y, Gu C, Morita M, et al. Y-box-binding protein-1 expression is not correlated with p53 expression but with proliferating cell nuclear antigen expression in non-small cell lung cancer. Anticancer Res. 2005; 25: 3437–3443.

    PubMed  CAS  Google Scholar 

  14. Mitsudomi T, Oyama T, Kusano T, Osaki T, Nakanishi R, Shirakusa T. Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small cell lung cancer. J Natl Cancer Inst. 1993; 85: 2018–2023.

    Article  PubMed  CAS  Google Scholar 

  15. Mitsudomi T, Oyama T, Nishida K, Ogami A, Osaki T, Sugio K, et al. Loss of heterozygosity at 3p in non-small cell lung cancer and its prognostic implication. Clin Cancer Res. 1996; 2: 1185–1189.

    PubMed  CAS  Google Scholar 

  16. Kawamoto T, Isse T, Kumugita N, Yang M, Kitagawa K, Suenaga R, et al. Effects of genetic polymorphism of drug metabolizing enzymes on smoking and drinking. J UOEH. 2003; 25: 97–106.

    Google Scholar 

  17. Evidence-Based Medicine Working Group. Evidence-based medicine. A new approach to teaching the practice of medicine. JAMA. 1992; 268: 2420–2425.

    Article  Google Scholar 

  18. Oyama T, Kawamoto T, Matsumoto A, Isse T, Ozaki S, Yasumoto K. Evidence based prevention (EBP): Evidencebased approach to prevention of lung cancer by application of cytochrome 2E1 polymorphism. J UOEH. 2002; 24: 413–421.

    PubMed  CAS  Google Scholar 

  19. Oyama T, Matsumoto A, Isse T, Kim Y-D, Ozaki S, Osaki T, et al. Evidence-based prevention (EBP): Approach to lung cancer prevention based on cytochrome 1A1 and cytochrome 2E1 polymorphism. Anticancer Res. 2003; 23: 1731–1738.

    PubMed  CAS  Google Scholar 

  20. Sobue T, Yamamoto S, Hara M, Sasazuki S, Sasaki S, Tsugane S, et al. Cigarette smoking and subsequent risk of lung cancer by histologic type in middle-aged Japanese men and women: the JPHC study. Int J Cancer. 2002; 99: 245–251.

    Article  PubMed  CAS  Google Scholar 

  21. Oyama T, Mitsudomi T, Kawamoto T, Ogami A, Osaki T, Kodama Y, et al. Detection of CYP1A1 gene polymorphism using designed RFLP and distributions of CYP1A1 genotypes in Japanese. Int Arch Occup Environ Health. 1995; 67: 253–256.

    Article  PubMed  CAS  Google Scholar 

  22. Oyama T, Kawamoto T, Mizoue T, Nishida K, Osaki T, Sugio K, et al. p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms. Int J. Oncol. 1997; 11: 305–309.

    CAS  Google Scholar 

  23. Oyama T, Kawamoto T, Mizoue T, Sugio K, Kodama Y, Mitsudomi T, et al. Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation. Anticancer Res. 1997; 17: 583–587.

    PubMed  CAS  Google Scholar 

  24. Oyama T, Osaki T, Mitsudomi T, Ogawa R, Nakanishi R, Sugio K, et al. p53 alteration, proliferating cell nuclear antigen, and nucleolar organizer regions in thymic epithelial tumors. Int J Mol Med. 1998; 1: 823–826.

    PubMed  CAS  Google Scholar 

  25. Oyama T, Osaki T, Nose N, Ichiki Y, Inoue M, Imoto H, et al. Evaluations of p53 immunoreactivity, nucleolar organizer regions, and proliferating cell nuclear antigen in nonsmall cell lung carcinoma. Anticancer Res. 2000; 20: 505–510.

    PubMed  CAS  Google Scholar 

  26. Kawajiri K, Eguchi H, Nakachi K, Sekiya T, Yamamoto M, Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer. Cancer Res. 1996; 56: 72–76.

    PubMed  CAS  Google Scholar 

  27. Oyama T, Kagawa N, Kim Y-D, Matsumoto A, Isse T, Kawamoto T. Lung cancer and CYP1A1 or GSTM1 polymorphism. Environ Health Prev Med. 2003; 7: 230–234.

    Article  CAS  Google Scholar 

  28. Ingelman-Sundberg M. Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes. Mutat Res. 2001; 482: 11–19.

    PubMed  CAS  Google Scholar 

  29. Goto I, Yoneda S, Yamamoto M, Kawajiri K. Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer. Cancer Res. 1996; 56: 3725–3730.

    PubMed  CAS  Google Scholar 

  30. Crawford EL, Weaver DA, DeMuth JP, Jackson CM, Khuder SA, Frampton MW, et al. Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells. Carcinogenesis. 1998; 19: 1867–1871.

    Article  PubMed  CAS  Google Scholar 

  31. Oyama T, Isse T, Kagawa N, Kinaga T, Kim YD, Morita M, et al. Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism. Front Biosci. 2005; 10: 951–960.

    Article  PubMed  CAS  Google Scholar 

  32. Hukkanen J, Pelkonen O, Hakkola J, Raunio H. Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung. Crit Rev Toxicol. 2002; 32: 391–411.

    Article  PubMed  CAS  Google Scholar 

  33. Berge G, Mollerup S, OVrebo S, Hewer A, Phillips DH, Eilertsen E, et al. Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung. Lung Cancer. 2004; 45: 289–297.

    Article  PubMed  Google Scholar 

  34. Port JL, Yamaguchi K, Du B, De Lorenzo M, Chang M, Heerdt PM, et al. Tobacco smoke induces CYP1B1 in the aerodigestive tract. Carcinogenesis. 2004; 25: 2275–2281.

    Article  PubMed  CAS  Google Scholar 

  35. Runge DM, Stock TW, Lehmann T, Taege C, Bernauer U, Stolz DB, et al. Expression of cytochrome P450 2E1 in normal human bronchial epithelial cells and activation by ethanol in culture. Arch Toxicol. 2001; 75: 335–337.

    Article  PubMed  CAS  Google Scholar 

  36. Raunio H, Hakkola J, Hukkanen J, Lassila A, Paivarinta K, Pelkonen O, et al. Expression of xenobiotic-metabolizing CYPs in human pulmonary tissue. Exp Toxicol Pathol. 1999; 51: 412–417.

    PubMed  CAS  Google Scholar 

  37. Raunio H, Hakkola J, Pelkonen O. Regulation of CYP3A genes in the human respiratory tract. Chem Biol Interact. 2005; 151: 53–62.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Environmental Health, University of Occupational and Environmental Health, 807-8555, Kitakyushu, Japan

    Tsunehiro Oyama, Toyohi Isse, Tomoe Murakami, Rie Suzuki-Narai, Masanori Ogawa, Tetsunosuke Yamaguchi, Tsuyoshi Kinaga, Yasunori Yashima, Shinichi Ozaki & Toshihiro Kawamoto

  2. Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea

    Yong-Dae Kim & Heon Kim

Authors
  1. Tsunehiro Oyama
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  2. Toyohi Isse
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  3. Tomoe Murakami
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  4. Rie Suzuki-Narai
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  5. Masanori Ogawa
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  6. Tetsunosuke Yamaguchi
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  7. Tsuyoshi Kinaga
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  8. Yasunori Yashima
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  9. Shinichi Ozaki
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  10. Yong-Dae Kim
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  11. Heon Kim
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  12. Toshihiro Kawamoto
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Correspondence to Tsunehiro Oyama.

Additional information

This article is based upon the research that was given Encouragement Award at the 75th Annual Meeting of the Japanese Society for Hygiene held in Niigata, Japan on March 27–30, 2005.

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Oyama, T., Isse, T., Murakami, T. et al. Evidence-based prevention (EBP): A review of cytochrome P450 expression in the bronchial epithelium and new approach to lung cancer prevention. Environ. Health Prev. Med. 11, 97–101 (2006). https://doi.org/10.1265/ehpm.11.97

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  • DOI: https://doi.org/10.1265/ehpm.11.97

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