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Long-Term Outcomes of Gastric Cancer Patients with Preoperative Sarcopenia

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

There are few reports of long-term outcomes of gastric cancer patients with sarcopenia. The purpose of this study was to assess the impact of sarcopenia on long-term outcomes in gastric cancer patients who underwent curative resection.

Methods

A total of 951 patients aged 65 years or older who underwent R0 resection for gastric cancer were investigated. Sarcopenia was defined as a decreased arm muscle area < 38.05 cm2 in men and < 27.87 cm2 in women combined with a decline in grip strength to < 26 kgf in men and < 18 kgf in women.

Results

Of 951 patients, 111 (11.7%) were diagnosed with sarcopenia. Reduced surgery was performed significantly more frequently in patients with sarcopenia (p = 0.006). The incidence of eligible patients who received adjuvant chemotherapy was significantly lower in patients with sarcopenia than in those without sarcopenia (p = 0.030). Mortality due to gastric cancer and aging-associated multiple organ failure rates without obvious diseases were higher in patients with sarcopenia (p = 0.036 and p < 0.001, respectively). Overall survival (OS) and cause-specific survival (CSS) were significantly worse in patients with sarcopenia (p < 0.001 and p = 0.005, respectively). Multivariate analysis for OS and CSS revealed that sarcopenia was an independent prognostic factor in gastric cancer patients (p < 0.001 and p = 0.043, respectively).

Conclusions

Sarcopenia is related to poor survival in gastric cancer patients and appears to be a significant negative prognostic factor in patients with gastric cancer who underwent curative resection.

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Authors and Affiliations

  1. Division of Gastric Surgery, Shizuoka Cancer Center, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan

    Taiichi Kawamura, Rie Makuuchi, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando & Masanori Terashima

  2. Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan

    Hiroshi Yasui

  3. Dietary Department, Shizuoka Cancer Center, Shizuoka, Japan

    Takashi Aoyama & Toshimi Inano

Authors
  1. Taiichi Kawamura
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  2. Rie Makuuchi
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  4. Yutaka Tanizawa
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  9. Masanori Terashima
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Correspondence to Masanori Terashima.

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Kawamura, T., Makuuchi, R., Tokunaga, M. et al. Long-Term Outcomes of Gastric Cancer Patients with Preoperative Sarcopenia. Ann Surg Oncol 25, 1625–1632 (2018). https://doi.org/10.1245/s10434-018-6452-3

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  • DOI: https://doi.org/10.1245/s10434-018-6452-3

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