Annals of Surgical Oncology

, Volume 25, Issue 6, pp 1625–1632 | Cite as

Long-Term Outcomes of Gastric Cancer Patients with Preoperative Sarcopenia

  • Taiichi Kawamura
  • Rie Makuuchi
  • Masanori Tokunaga
  • Yutaka Tanizawa
  • Etsuro Bando
  • Hiroshi Yasui
  • Takashi Aoyama
  • Toshimi Inano
  • Masanori Terashima
Gastrointestinal Oncology



There are few reports of long-term outcomes of gastric cancer patients with sarcopenia. The purpose of this study was to assess the impact of sarcopenia on long-term outcomes in gastric cancer patients who underwent curative resection.


A total of 951 patients aged 65 years or older who underwent R0 resection for gastric cancer were investigated. Sarcopenia was defined as a decreased arm muscle area < 38.05 cm2 in men and < 27.87 cm2 in women combined with a decline in grip strength to < 26 kgf in men and < 18 kgf in women.


Of 951 patients, 111 (11.7%) were diagnosed with sarcopenia. Reduced surgery was performed significantly more frequently in patients with sarcopenia (p = 0.006). The incidence of eligible patients who received adjuvant chemotherapy was significantly lower in patients with sarcopenia than in those without sarcopenia (p = 0.030). Mortality due to gastric cancer and aging-associated multiple organ failure rates without obvious diseases were higher in patients with sarcopenia (p = 0.036 and p < 0.001, respectively). Overall survival (OS) and cause-specific survival (CSS) were significantly worse in patients with sarcopenia (p < 0.001 and p = 0.005, respectively). Multivariate analysis for OS and CSS revealed that sarcopenia was an independent prognostic factor in gastric cancer patients (p < 0.001 and p = 0.043, respectively).


Sarcopenia is related to poor survival in gastric cancer patients and appears to be a significant negative prognostic factor in patients with gastric cancer who underwent curative resection.



The authors have no financial disclosures.


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Copyright information

© Society of Surgical Oncology 2018

Authors and Affiliations

  • Taiichi Kawamura
    • 1
  • Rie Makuuchi
    • 1
  • Masanori Tokunaga
    • 1
  • Yutaka Tanizawa
    • 1
  • Etsuro Bando
    • 1
  • Hiroshi Yasui
    • 2
  • Takashi Aoyama
    • 3
  • Toshimi Inano
    • 3
  • Masanori Terashima
    • 1
  1. 1.Division of Gastric SurgeryShizuoka Cancer CenterShizuokaJapan
  2. 2.Division of Gastrointestinal OncologyShizuoka Cancer CenterShizuokaJapan
  3. 3.Dietary DepartmentShizuoka Cancer CenterShizuokaJapan

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