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Dissemination of Minimally Invasive Liver Resection for Primary Malignancy: Reevaluating Effectiveness

  • Hepatobiliary Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Experiences at specialized hepatobiliary centers have demonstrated efficacy of minimally invasive liver resection, but concerns exist regarding whether these procedures would remain effective once disseminated to a broad range of clinical practices. We sought to present the first comparison of MILR and open liver resection (OLR) for primary liver malignancy from a nationally representative cancer registry.

Methods

Cases of liver and intrahepatic bile duct cancer were identified from the National Cancer Data Base Participant Use File. Mixed effects logistic regression and stratified Cox proportional hazards regression were used for analysis. A propensity score matched cohort was used as an alternative form of analysis to evaluate the robustness of results.

Results

A total of 3236 cases were analyzed from 2010 to 2011 with 2581 OLR (80%) and 655 MILR (20%). Of the variation in patient selection for MILR 28.5% was related to treatment at a specific treatment center; however, the proportion of MILR was similar among low-, medium-, and high-volume centers. Overall 90-day mortality was lower at high-volume centers (odds ratio [OR] 0.58; 95% confidence interval [CI] 0.40–0.85) compared with low-volume centers. MILR was similar to OLR in both 90-day mortality and overall survival (OR 0.9; 95% CI 0.62–1.10) and hazard ratio [HR] 0.88 (95% CI 0.72–1.07), regardless of treatment center volume.

Conclusions

MILR for primary liver malignancy is used across a variety of practice settings, with similar outcomes to OLR. While volume is associated with short-term outcomes of liver resection as a whole, this relationship is not explained by adoption of MILR at low-volume centers.

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Grant Support

NIH T32 GM008516-21(PRV).

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Authors and Affiliations

  1. Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Patrick R. Varley MD, MSc, Samer T. Tohme MD, Alexis P. Chidi MD, PhD, Julie Goswami MD, Dirk van der Windt MD, PhD, David A. Geller MD & Allan Tsung MD

  2. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA

    Allan Tsung MD

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  1. Patrick R. Varley MD, MSc
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  2. Samer T. Tohme MD
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  3. Alexis P. Chidi MD, PhD
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Correspondence to Allan Tsung MD.

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Varley, P.R., Tohme, S.T., Chidi, A.P. et al. Dissemination of Minimally Invasive Liver Resection for Primary Malignancy: Reevaluating Effectiveness. Ann Surg Oncol 25, 808–817 (2018). https://doi.org/10.1245/s10434-017-6308-2

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  • DOI: https://doi.org/10.1245/s10434-017-6308-2

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