Annals of Surgical Oncology

, Volume 25, Issue 3, pp 694–701 | Cite as

Prediction of Resectability in Pseudomyxoma Peritonei with a New CT Score

  • Morgane Bouquot
  • Anthony Dohan
  • Etienne Gayat
  • Maxime Barat
  • Olivier Glehen
  • Marc Pocard
  • Pascal Rousset
  • Clarisse Eveno
Colorectal Cancer

Abstract

Background

Curative treatment of pseudomyxoma peritonei (PMP) is complete cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC).

Objective

The aim of this study was to build and evaluate a preoperative imaging score to predict resectability.

Patients and methods

Between 2007 and 2014, all PMP patients in two tertiary reference centers who underwent laparotomy with intent to undergo CRS and HIPEC were included in this study retrospectively. Thickness of tumor burden was measured on preoperative multidetector-row computed tomography (MDCT) by two radiologists blinded to surgical results in five predetermined areas. Patients were divided into two cohorts with the same resectability rate (building and validation). The performances of the scores were assessed using receiver operating characteristic (ROC) curve analyses.

Results

Overall, 126 patients were included, with compete CRS being achieved in 91/126 patients (72.2%). Two cohorts of 63 patients matched by age, sex, burden of disease, resectability rate, and pathological grade were constituted. The MDCT score was the sum of the five measures, and was higher in unresectable disease [median 46.2 mm (range 27.9–74.6) vs. 0.0 mm (range 0.0–14.0), p < 0.001]. Area under the ROC curve was 0.863 (range 0.727–0.968) and 0.801 (range 0.676–0.914) in the building and validation cohorts, respectively. A threshold of 28 mm yielded a sensitivity, specificity, positive predictive and negative predictive value of 94, 81, 81 and 94% in the building cohort, and 80, 68, 59 and 85% in the validation cohort, respectively. Using our score, overall and disease-free survival were increased in the group classified as resectable.

Conclusion

A simple preoperative MDCT score measuring tumor burden in the perihepatic region is able to predict resectability and survival of PMP patients.

Notes

Disclosures

Morgane Bouquot, Anthony Dohan, Etienne Gayat, Maxime Barat, Olivier Glehen, Marc Pocard, Pascal Rousset, and Clarisse Eveno have no financial or other personal conflicts of interest to declare.

Author Contributions

Morgane Bouquot contributed to the acquisition of data, writing of the manuscript and analysis of data. Anthony Dohan, Maxime Barat and Clarisse Eveno contributed to development of the methodology, interpretation of data, and conception, design, and review of the manuscript. Etienne Gayat contributed to development of the methodology, analysis and interpretation of data, and writing and review of the manuscript. Olivier Glehen and Marc Pocard contributed to revision of the manuscript and study supervision. Pascal Rousset contributed to acquisition and analysis of data, and review of the manuscript.

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Copyright information

© Society of Surgical Oncology 2017

Authors and Affiliations

  • Morgane Bouquot
    • 1
    • 7
  • Anthony Dohan
    • 2
    • 7
  • Etienne Gayat
    • 3
    • 7
  • Maxime Barat
    • 2
  • Olivier Glehen
    • 4
  • Marc Pocard
    • 5
    • 7
  • Pascal Rousset
    • 6
  • Clarisse Eveno
    • 5
    • 7
  1. 1.Department of Digestive and Oncological SurgeryHôpital Lariboisière-AP-HPParisFrance
  2. 2.Department of Body and Interventional Imaging, Hôpital Cochin-AP-HPUniversité Sorbonne Paris Cité – Paris DescartesParisFrance
  3. 3.Department of Anesthesiology and Critical Care Medicine, Hôpital Lariboisière-AP-HPUniversité Sorbonne Paris Cité – Paris DiderotParisFrance
  4. 4.Department of Digestive and Oncologic Surgery, Centre Hospitalier Lyon Sud – HCLLyon 1 University Pierre-BéniteLyonFrance
  5. 5.Department of Digestive and Oncological Surgery, Hôpital Lariboisière-AP-HPSorbonne Paris Cité – Paris DiderotParisFrance
  6. 6.Department of Radiology, Centre Hospitalier Lyon Sud – HCLLyon 1 University Pierre-BéniteLyonFrance
  7. 7.INSERM U 965ParisFrance

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