Annals of Surgical Oncology

, Volume 24, Issue 12, pp 3617–3623 | Cite as

The Impact of Nodal Dissection on Staging in Adrenocortical Carcinoma

  • Suraj Panjwani
  • Maureen D. Moore
  • Katherine D. Gray
  • Brendan M. Finnerty
  • Toni Beninato
  • Laurent Brunaud
  • Thomas J. FaheyIII
  • Rasa Zarnegar
Endocrine Tumors

Abstract

Background

The role of lymphadenectomy in adrenocortical carcinoma (ACC) is controversial, and formal lymph node (LN) dissection is not routine. We sought to determine the minimum number of LNs that must be examined to accurately identify a patient as node negative.

Methods

The National Cancer Database was used to identify patients diagnosed with ACC from 2004 to 2013 who underwent surgical resection. Patients with distant metastases, multivisceral resection, or missing surgical or lymphadenectomy data were excluded. The primary outcome was overall survival (OS).

Results

LNs were identified on histopathology in 156 patients. Of these, 35 (22%) had at least one positive LN. Positive LNs were associated with positive surgical margins (odds ratio [OR] 5.80, p = 0.002) and increasing LN yield (OR 1.06, p = 0.02). Overall, on Cox regression analysis, LN positivity (hazard ratio [HR] 3.02, p < 0.001) and positive surgical margins (HR 2.06, p = 0.048) independently predicted poor OS after controlling for other factors that may influence survival. LN(−) disease in patients with one to three LNs examined had poorer overall survival compared with when at least four LNs were examined (p = 0.02). None of the other patient, tumor, and treatment variables had any impact on OS of the LN(−) cohort. The likelihood of identifying nodal involvement was higher on examination of at least four LNs compared with examination of one to three LNs (30 vs. 16%, p = 0.03).

Conclusions

LN positivity in ACC tumors independently predicts worse 5-year OS and a minimum of four LNs may be required to accurately determine LN negativity.

Notes

Acknowledgment

None.

Disclosure

The CoC’s NCDB and the hospitals participating in the CoC NCDB are the source of the de-identified data used. They have not verified and are not responsible for the statistical validity of the data analysis or the conclusions derived by the authors.

Supplementary material

10434_2017_6064_MOESM1_ESM.tif (4.1 mb)
Supplementary Fig. 1 Inclusion and exclusion criteria. Supplementary material 1 (TIFF 4152 kb)
10434_2017_6064_MOESM2_ESM.docx (13 kb)
Supplementary material 2 (DOCX 13 kb)

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Copyright information

© Society of Surgical Oncology 2017

Authors and Affiliations

  • Suraj Panjwani
    • 1
  • Maureen D. Moore
    • 1
  • Katherine D. Gray
    • 1
  • Brendan M. Finnerty
    • 1
  • Toni Beninato
    • 1
  • Laurent Brunaud
    • 2
  • Thomas J. FaheyIII
    • 1
  • Rasa Zarnegar
    • 1
  1. 1.Department of SurgeryNew York Presbyterian Hospital – Weill Cornell MedicineNew YorkUSA
  2. 2.Digestive, Hepato-Biliary and Endocrine Surgery, CHU Nancy-Hospital Brabois AdultesUniversity de LorraineNancyFrance

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