Annals of Surgical Oncology

, Volume 24, Issue 12, pp 3477–3485 | Cite as

Hospitalization in the Year Preceding Major Oncologic Surgery Increases Risk for Adverse Postoperative Events

  • Catherine E. Sharoky
  • Karole T. Collier
  • Christopher J. Wirtalla
  • Andrew J. Sinnamon
  • Madalyn G. Neuwirth
  • Lindsay E. Kuo
  • Robert E. Roses
  • Douglas L. Fraker
  • Giorgos C. Karakousis
  • Rachel R. Kelz
Health Services Research and Global Oncology



Hospitalization is associated with negative clinical effects that last beyond discharge. This study aimed to determine whether hospitalization in the year before major oncologic surgery is associated with adverse outcomes.


Patients 18 years of age or older with stomach, pancreas, colon, or rectal cancer who underwent resection in California and New York (2008–2010) were included in the study. Patients with hospitalization in the year prior to oncologic resection (HYPOR) were identified. Multivariable logistic regression was used to examine the association of prior hospitalization with the following adverse outcomes: inpatient mortality, complications, complex discharge needs, and 90-day readmission. Subset analysis by cancer type was performed. Outcomes based on temporal proximity of hospitalization to month of surgical admission were evaluated.


Of 32,292 patients, 16.3% (n = 5276) were HYPOR. Patients with prior hospitalization were older (median age, 72 vs 67 years; p < 0.001) and had more comorbidities (Elixhauser Index ≥3, 86.5 vs 75.3%; p < 0.001). In the multivariable analysis, HYPOR was associated with complications (odds ratio [OR], 1.28; 95% confidence interval [CI] 1.18–1.40), complex discharge (OR, 1.44; 95% CI 1.34–1.55), and 90-day readmission (OR, 1.45; 95% CI 1.35–1.56). The interval from HYPOR to resection was not associated with adverse outcomes.


Patients hospitalized in the year before oncologic resection are at increased risk for postoperative adverse events. Recent hospitalization is a risk factor that is easily ascertainable and should be used by clinicians to identify patients who may need additional support around the time of oncologic resection.


Conflict of interest

There are no conflicts of interest.


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Copyright information

© Society of Surgical Oncology 2017

Authors and Affiliations

  • Catherine E. Sharoky
    • 1
  • Karole T. Collier
    • 1
  • Christopher J. Wirtalla
    • 1
  • Andrew J. Sinnamon
    • 1
  • Madalyn G. Neuwirth
    • 1
  • Lindsay E. Kuo
    • 1
  • Robert E. Roses
    • 2
  • Douglas L. Fraker
    • 2
  • Giorgos C. Karakousis
    • 1
    • 2
  • Rachel R. Kelz
    • 1
    • 2
  1. 1.Department of Surgery, Center for Surgery and Health EconomicsHospital of the University of PennsylvaniaPhiladelphiaUSA
  2. 2.Division of Endocrine and Oncologic Surgery, Department of SurgeryHospital of the University of PennsylvaniaPhiladelphiaUSA

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