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Perioperative Adiponectin Measurement is Useful for Prediction of Postoperative Infection in Patients with Colorectal Cancer

  • Translational Research and Biomarkers
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Adiponectin (ADN) is a key molecule associated with obesity and metabolic syndrome, and functions as an immunomodulator. We have shown that the ADN ratio (i.e., postoperative ADN/preoperative ADN) can predict infection after gastrectomy in patients with gastric cancer . In the present study, we evaluated whether the ADN ratio could reliably predict the incidence of postoperative infection in patients undergoing colorectal cancer surgery.

Methods

We retrospectively analyzed 131 consecutive patients who underwent colorectal cancer surgery and measured their preoperative and postoperative ADN values. The outcome was postoperative infection, including surgical site and remote infections. The association between the ADN ratio and postoperative infection was assessed using logistic regression models. For the ADN ratio and other significant predictors, we conducted receiver operating characteristics (ROC) analyses.

Results

Forty-nine patients (37.4 %) experienced postoperative infections. Logistic regression analysis indicated that the ADN ratio was most significantly associated with postoperative infection [odds ratio per one standard deviation (1 SD) decrease 0.36; 95 % confidence interval 0.18–0.71] even after adjustment for diabetes, type of surgery, blood loss, C-reactive protein level, and preoperative ADN level. History of type 2 diabetes mellitus also significantly predicted postoperative infection (odds ratio per 1 SD increase 2.93; 95 % confidence interval 1.03–8.38). When predicting postoperative infection, the area under the ROC curve for the ADN ratio (0.707) was comparable to that for blood loss (0.698; p = 0.975).

Conclusions

ADN ratio is a clinically useful predictor of postoperative infection in patients undergoing colorectal cancer.

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Acknowledgment

We sincerely appreciate the cooperation of Etsuko Tsubakino, Hirofumi Yumoto, Ikuko Arikawa, Ai Kenmochi, and Miho Yamamoto for technical assistance. This work was supported by a Grant-in-Aid for Scientific Research (C), a Grant-in-Aid for the Cooperative Research Project from Joint Usage/Research Center (Joint Usage/Research Center for Science-Based Natural Medicine) Institute of Natural Medicine, University of Toyama, in 2015, as well as, in part, a grant from Otsuka Pharmaceutical Co. Ltd.

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Authors and Affiliations

  1. Department of Surgery, Shiga University of Medical Science, Shiga, Japan

    Hiroshi Yamamoto MD, PhD, Hiromichi Sonoda MD, PhD, Tomoharu Shimizu MD, PhD, Sachiko Kaida MD, PhD, Tsuyoshi Yamaguchi MD, PhD, Satoshi Murata MD, PhD & Masaji Tani MD, PhD

  2. Department of Metabolic Medicine, Osaka University Hospital, Osaka, Japan

    Kazuhisa Maeda MD, PhD

  3. Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Hisatomi Arima MD, PhD

  4. Department of Comprehensive Surgery, Shiga University of Medical Science, Shiga, Japan

    Eiji Mekata MD, PhD

  5. Department of Public Health, Shiga University of Medical Science, Shiga, Japan

    Katsuyuki Miura MD, PhD

  6. Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Shiga, Japan

    Katsuyuki Miura MD, PhD

  7. Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan

    Makoto Kadowaki MD, PhD

Authors
  1. Hiroshi Yamamoto MD, PhD
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  2. Kazuhisa Maeda MD, PhD
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  3. Hisatomi Arima MD, PhD
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  8. Tsuyoshi Yamaguchi MD, PhD
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Corresponding author

Correspondence to Hiroshi Yamamoto MD, PhD.

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Yamamoto, H., Maeda, K., Arima, H. et al. Perioperative Adiponectin Measurement is Useful for Prediction of Postoperative Infection in Patients with Colorectal Cancer. Ann Surg Oncol 23 (Suppl 4), 540–545 (2016). https://doi.org/10.1245/s10434-016-5386-x

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  • DOI: https://doi.org/10.1245/s10434-016-5386-x

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