Annals of Surgical Oncology

, Volume 23, Issue 12, pp 3956–3963 | Cite as

Significant Role of Palliative Gastrectomy in Selective Gastric Cancer Patients with Peritoneal Dissemination: A Propensity Score Matching Analysis

  • Run-Cong Nie
  • Shi Chen
  • Shu-Qiang Yuan
  • Xiao-Jiang Chen
  • Yong-Ming Chen
  • Bao-Yan Zhu
  • Hai-bo Qiu
  • Jun-Sheng Peng
  • Ying-Bo Chen
Gastrointestinal Oncology

Abstract

Objective

The aim of this study was to explore whether palliative gastrectomy is suitable for gastric cancer patients with peritoneal metastasis, and for patients in whom the type of peritoneal metastasis should be selected to receive palliative gastrectomy.

Methods

A total of 747 patients diagnosed with gastric adenocarcinoma with peritoneal metastasis at our centers between January 2000 and April 2014 were retrospectively analyzed. After propensity score matching, the clinicopathologic characteristics and clinical outcomes of patients with peritoneal dissemination were analyzed.

Results

After propensity score matching, the median overall survival (OS) of patients in the gastrectomy group was longer than that for patients in the non-gastrectomy group (11.87 vs. 9.27 months; p = 0.020). Patients who received first-line chemotherapy had a significantly longer median OS than those who did not (11.97 vs. 7.03 months; p < 0.001); among these patients, those undergoing more than eight periods of first-line chemotherapy benefited the most (p < 0.001). Subgroup analyses revealed that patients classified as P1 who were undergoing chemotherapy benefited from gastrectomy (p = 0.024), and patients without multisite metastasis also benefited from gastrectomy with regard to OS (p = 0.007). In the multivariate survival analysis, multisite distant metastasis was the independent poor prognostic factor (p < 0.001), while palliative gastrectomy (p = 0.006) and a period of first-line chemotherapy (p < 0.001) were good prognostic factors. Morbidity rates in the gastrectomy and non-gastrectomy groups were 10.4 and 1.0 %, respectively (p = 0.003); however, no difference in mortality was noted between the two groups (p = 0.590).

Conclusions

Palliative gastrectomy can prolong the survival of P1 patients without multisite distant metastasis when combined with more than five periods, and particularly more than eight periods, of first-line chemotherapy.

Keywords

Gastric Cancer Overall Survival Propensity Score Gastric Cancer Patient Median Overall Survival 

Notes

Acknowledgments

The authors thank Dr. Zhiwei Zhou, Yuanfang Li, and Yupei Chen for their encouragement, support and valuable statistical help. This work was supported in part by a grant from the National Natural Science Foundation of China (81,302,144) and the Guangdong Science and Technology Department (No. 2012B0617000879).

Compliance with Ethical Standards

Disclosures

Run-Cong Nie, Shi Chen, Shu-Qiang Yuan, Xiao-Jiang Chen, Yong-Ming Chen, Bao-Yan Zhu, Hai-bo Qiu, Jun-Sheng Peng, and Ying-Bo Chen report no financial disclosures.

Supplementary material

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Supplementary material 1 (TIFF 1717 kb)
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Supplementary material 2 (TIFF 1671 kb)
10434_2016_5223_MOESM3_ESM.docx (16 kb)
Supplementary material 3 (DOCX 16 kb)

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Copyright information

© Society of Surgical Oncology 2016

Authors and Affiliations

  • Run-Cong Nie
    • 1
  • Shi Chen
    • 2
  • Shu-Qiang Yuan
    • 1
  • Xiao-Jiang Chen
    • 1
  • Yong-Ming Chen
    • 1
  • Bao-Yan Zhu
    • 1
  • Hai-bo Qiu
    • 1
  • Jun-Sheng Peng
    • 2
  • Ying-Bo Chen
    • 1
  1. 1.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina
  2. 2.Department of Gastric Surgery, The 6th Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

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