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Prognosis of Primary and Recurrent Chondrosarcoma of the Rib

  • Bone and Soft Tissue Sarcomas
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Chondrosarcoma of the rib is a rare disease. Although surgery is the only curative treatment option, rib resection with an adequate margin can be challenging and local recurrence is a frequent problem. In this study, the prognosis of primary and recurrent chondrosarcoma of the rib is reported.

Methods

Retrospective analysis was performed of patients treated for chondrosarcoma of the rib between 1984 and 2014 in three major tertiary referral centers in The Netherlands. Clinical and histopathological features were analyzed for their prognostic value using Kaplan–Meier and Cox proportional hazard analysis. Endpoints were set at local recurrent disease, metastasis rate, or death.

Results

Overall, 76 patients underwent a resection for a primary chondrosarcoma, and 26 patients underwent a resection for a recurrent chondrosarcoma. Five-year overall survival in the primary group was 90 %, local recurrence rate was 17 %, and metastasis rate was 12 %. The 5-year outcome after recurrent chondrosarcoma was lower, with an overall survival of 65 %, local recurrence rate of 27 %, and metastasis rate of 27 %. For primary chondrosarcoma, tumor size >5 cm and a positive resection margin were correlated with worse overall survival [hazard ratio (HR) 3.28, 95 % confidence interval (CI) 1.03–10.44; HR 2.92, 95 % CI 1.03–8.25). A higher histological grade was correlated with a higher local recurrence and metastasis rate (HR 5.92, 95 % CI 1.11–31.65; HR 6.96, 95 % CI 1.15–42.60).

Conclusion

Surgical resection of both primary and recurrent chondrosarcoma of the rib is an effective treatment strategy. The oncological outcome after surgery is worse in tumors >5 cm, in tumors with positive resection margins and grade 3 chondrosarcoma.

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Acknowledgments

Winan J. van Houdt was supported by the Dutch Cancer Society with a clinical fellowship on sarcoma (Grant Number NKI 2014-6). We would like to thank the the Netherlands Committee on Bone Tumors for allowing us to use its archives for this study.

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Authors and Affiliations

  1. Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    Eva Roos MD, Frits van Coevorden MD, PhD, Michel W. Wouters MD, PhD & Winan J. van Houdt MD, PhD, MSc

  2. Department of Surgical Oncology, Erasmus Medical Centre–Daniel den Hoed, Rotterdam, The Netherlands

    Cornelis Verhoef MD, PhD

  3. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

    Herman M. Kroon MD, PhD

  4. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

    Pancras C. W. Hogendoorn MD, PhD

Authors
  1. Eva Roos MD
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  2. Frits van Coevorden MD, PhD
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  3. Cornelis Verhoef MD, PhD
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  4. Michel W. Wouters MD, PhD
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  5. Herman M. Kroon MD, PhD
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  6. Pancras C. W. Hogendoorn MD, PhD
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  7. Winan J. van Houdt MD, PhD, MSc
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Corresponding author

Correspondence to Winan J. van Houdt MD, PhD, MSc.

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Roos, E., van Coevorden, F., Verhoef, C. et al. Prognosis of Primary and Recurrent Chondrosarcoma of the Rib. Ann Surg Oncol 23, 811–817 (2016). https://doi.org/10.1245/s10434-015-4932-2

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  • DOI: https://doi.org/10.1245/s10434-015-4932-2

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