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Annals of Surgical Oncology

, Volume 22, Supplement 3, pp 1587–1593 | Cite as

TGF Beta1 Expression Correlates with Survival and Tumor Aggressiveness of Prostate Cancer

  • Chun-Te Wu
  • Ying-Hsu Chang
  • Wei-Yu Lin
  • Wen-Cheng Chen
  • Miao-Fen Chen
Urologic Oncology

Abstract

Background

Although biopsy Gleason score and clinical stage can be used to inform treatment decisions for prostate cancer, identifying molecular markers of tumor aggressiveness could lead to a more tailored approaches to therapy. In the present study, we investigated the association of transforming growth factor (TGF)-β1 levels and various markers of tumor aggressiveness and explore some potential mechanisms underlying the associations.

Methods

We used human and murine prostate cancer cell lines and their respective hormone resistance sub-lines, in vitro and in vivo to examine the changes in tumor aggressiveness, as well as the pathway responsible for these changes. Furthermore, 105 prostate cancer biopsy specimens were analyzed to correlate the level of TGF-β1 with the clinical characteristics of patients.

Results

Our data revealed that activated TGF-β1 signaling resulted in more aggressive tumor growth and augmented the epithelial–mesenchymal transition. Activated IL-6 signaling was associated with TGF-β1 levels and the aggressive tumor features noted in TGF-β1-positive prostate cancers in vitro and in vivo. Furthermore, the TGF-β1 levels significantly correlated with Tregs accumulation in vivo. The clinical data indicated that TGF-β1 immunoreactivity had a moderate positive correlation with IL-6 staining, advanced clinical stage, higher Gleason score, and pretreatment PSA in patients with prostate cancer.

Conclusions

TGF-β1 levels are significantly associated with aggressive prostate features. In vitro and in vivo alternations of TGF-β1 expression impacts tumor invasiveness, tumor growth rate and recruitment of immunosuppressive Treg cells in the tumor microenvironment. TGF-β1 expression may represent a clinical useful biomarker to guide prostate cancer treatment decisions.

Keywords

Prostate Cancer Prostate Cancer Cell Gleason Score Hormone Resistance Aggressive Prostate Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The study was supported by National Science Council, Taiwan. Grant 101-2314-B-182-062-MY3.

Disclosure

There is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Supplementary material

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Copyright information

© Society of Surgical Oncology 2015

Authors and Affiliations

  • Chun-Te Wu
    • 1
    • 2
  • Ying-Hsu Chang
    • 2
    • 3
  • Wei-Yu Lin
    • 2
    • 4
  • Wen-Cheng Chen
    • 2
    • 5
  • Miao-Fen Chen
    • 2
    • 5
  1. 1.Department of UrologyChang Gung Memorial Hospital at KeelungKeelungTaiwan
  2. 2.College of MedicineChang Gung UniversityTaoyuanTaiwan
  3. 3.Department of UrologyChang Gung Memorial Hospital at LinkoLinkoTaiwan
  4. 4.Department of UrologyChang Gung Memorial Hospital at ChiayiChiayiTaiwan
  5. 5.Department of Radiation OncologyChang Gung Memorial Hospital at ChiayiChiayiTaiwan

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