Annals of Surgical Oncology

, Volume 22, Issue 13, pp 4187–4192 | Cite as

Pediatric Thyroid Microcarcinoma

  • Jonathan Lerner
  • Melanie Goldfarb
Endocrine Tumors



Thyroid microcarcinomas (TMCs) are increasing in the general population, most commonly in older individuals; however, the incidence, characteristics, and outcomes of TMCs in pediatric patients has not been studied.


All patients ≤19 years of age with differentiated thyroid carcinoma (DTC) were identified from the surveillance, epidemiology, and end results registry from 1988 to 2009. Patients were divided into two groups based on tumor siz e: TMCs (≤1 cm) and tumors >1 cm. Demographic, tumor, and treatment characteristics, as well as overall survival (OS) and disease-specific survival (DSS), were compared between the two groups. The TMC group was analyzed separately for predictors of overall and disease-specific death.


Of 1825 pediatric DTC patients, 8.4 % had a TMC, and, over the past decade, the incidence has decreased (6.5 vs 14.5 %; p < 0.001). Compared to patients with DTCs >1 cm, TMCs were more likely to have papillary histology, negative lymph nodes, be treated with a partial thyroidectomy [odds ratio (OR) 3.46, CI 2.02–5.93] and not receive radioiodine (OR 1.77, CI 1.10–2.83). Neither OS (TMC: 253.59 months; DTC >1 cm: 257.97 months) nor DSS (TMC: 256.38 months; DTC >1 cm: 260.77 months) differed between groups. Predictors of decreased OS in the entire cohort included secondary malignancy status (p = 0.001), black race (p = 0.006) and follicular or Hurthle histology (p = 0.001). In patients with primary TMC, only follicular or Hurthle histology (p = 0.001) predicted decreased OS.


TMCs in patients ≤19 years of age are declining and comprise <10 % of pediatric thyroid malignancies. TMCs are most commonly treated with a partial thyroidectomy not followed by radioiodine, and have an excellent OS and DSS.


Overall Survival Differentiate Thyroid Carcinoma Extrathyroidal Extension Differentiate Thyroid Carcinoma Patient Partial Thyroidectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Jonathan Lerner and Melanie Goldfarb have no conflicts of interest to declare, nor any financial disclosures to report.


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Copyright information

© Society of Surgical Oncology 2015

Authors and Affiliations

  1. 1.University of Southern California Keck School of MedicineLos AngelesUSA
  2. 2.Endocrine Tumor ProgramJohn Wayne Cancer Institute at Providence St. John’s Health CenterSanta MonicaUSA

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