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Annals of Surgical Oncology

, Volume 22, Issue 3, pp 959–965 | Cite as

Perforation in Appendiceal Well-Differentiated Carcinoid and Goblet Cell Tumors: Impact on Prognosis? A Systematic Review

  • Ariana Madani
  • Jarmila D. W. van der Bilt
  • Esther C. J. Consten
  • Menno R. Vriens
  • Inne H. M. Borel Rinkes
Endocrine Tumors

Abstract

Background

Carcinoid tumors are the most common malignant lesions arising from Appendix and are mostly found incidentally during surgery for appendicitis. Perforation of Appendix occurs in 10–20 % of cases with appendicitis. Currently, no guidelines exist for the treatment of perforated carcinoids of Appendix.

Methods

A systematic literature search was performed to identify relevant articles on classical carcinoid or goblet cell carcinoid of Appendix in an attempt to evaluate the impact of perforation on management and prognosis. All articles on carcinoids reporting perforation of Appendix were included.

Results

In total, 23 articles on carcinoid of Appendix with an associated perforation were found. Perforation was never investigated or mentioned as a possible negative factor on recurrence or prognosis. Among a total of 103 patients with classical carcinoids and associated perforation, no peritoneal recurrence or death was described, although follow-up data were often unspecified or scarce. Among a total of 18 goblet cell carcinoids with perforation, metastatic spread to the peritoneum was described in one case and two tumor-related deaths occurred among these cases. No specific relation to perforation could be distilled.

Conclusions

The best available evidence suggests that perforation has no influence on prognosis of classical appendiceal carcinoids. In contrast, peritoneal carcinomatosis is much more common in goblet cell carcinoids but the true impact of perforation remains unclear. Careful follow-up should therefore be considered in these cases.

Keywords

Perforation Appendicitis Neuroendocrine Tumor Carcinoid Tumor Peritoneal Carcinomatosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Disclosures

None.

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Copyright information

© Society of Surgical Oncology 2014

Authors and Affiliations

  • Ariana Madani
    • 1
  • Jarmila D. W. van der Bilt
    • 1
  • Esther C. J. Consten
    • 2
  • Menno R. Vriens
    • 1
  • Inne H. M. Borel Rinkes
    • 1
  1. 1.Department of SurgeryUniversity Medical Center UtrechtUtrechtThe Netherlands
  2. 2.Department of SurgeryMeander Medical CenterAmersfoortThe Netherlands

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